Research Interest: Many bacteria have the amazing ability to switch between different lifestyles, between living in the fluid and dwelling in a biofilm. This flexible strategy presumably increases their competence in a fluctuating environment. Using V. cholerae as the model organism and combing microscopy, microfluidic, and genetic tools, I am testing this ecological hypothesis that is naturally linked to the infectious cycle of V.cholerae. At the same time, I am uncovering the molecular mechanism of the less understood dispersal process. By developing fluorescent reporters, I wish to observe the spatial heterogeneity in the gene expression within a biofilm, which will reveal how the complicated processes of biofilm formation and disintegration are actively controlled, both spatially and temporally.