Publications Archive

Giguère SS, Guise AJ, Jean Beltran PM1, ... Kong J, Cristea IM. (2015) The proteomic profile of deleted in breast cancer 1 (DBC1) interactions points to a multi-faceted regulation of gene expression. Mol Cell Proteomics.
[Epub ahead of print]

Budayeva HG, Rowland EA, Cristea IM. (2015) The intricate roles of mammalian sirtuins in defense against viral pathogens. J Virol. [Epub ahead of print]

Lin KW, McDonald KR, Guise AJ, Chan A, Cristea IM, Zakian VA. (2015) Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length. Nat Commun.  6:8290. Pubmed

Diner BA, Cristea IM. (2015) Blowing off steam: Virus inhibition of cGAS DNA sensing.  Cell Host Microbe. 18(3):270-2. Pubmed

Diner BA, Lum KK, Cristea IM. (2015) The emerging role of nuclear viral DNA sensors. J Biol Chem.  [Epub ahead of print]

Orzalli MH, Broekema NM,..., Elde NC, Cristea IM, Knipe DM. (2015) cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection. Proc Natl Acad Sci U S A.  10: 10732. PubMed

Koyuncu OO, Song R, Greco TM, Cristea IM, Enquist LW. (2015) The number of alphaherpesvirus particles infecting axons and the axonal protein repertoire determines the outcome of neuronal infection. MBio. 6. pii: e00276-15. Pubmed

Rowles DL, Tsai YC, Greco TM, Lin AE, Li M, Yeh J, Cristea IM. (2015) The DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection. Proteomics. [Epub ahead of print]

Crow MS, Javitt A, Cristea IM. (2015) A proteomics perspective on viral DNA sensors in host defense and viral immune evasion mechanisms. J Mol Biol. 427:1995-2012.  Pubmed

Diner BA, Lum KK, Javitt A, Cristea IM. (2015) Interactions of the antiviral factor IFI16 mediate immune signaling and herpes simplex virus-1 immunosuppression. Mol Cell Proteomics. [Epub ahead of print]

Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM. (2015) The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol. 11:787. Pubmed

Mathias RA, Guise AJ, Cristea IM. (2015) Post-translational modifications regulate class IIa histone deacetylase function in health and disease. Mol Cell Proteomics. 14:456-470 Pubmed

Koyuncu E, Budayeva HG, Miteva YV,...Cristea IM. (2014) Sirtuins are evolutionarily conserved viral restriction factors. MBio. 5. pii: e02249-14. Pubmed

Mathias RA, Greco TM, Oberstein A,...Cristea IM. (2014) Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell. 159: 1615-25. Pubmed

Castellana M, Wilson MZ, Xu Y, Joshi P, Cristea IM, Rabinowitz JD, Gitai Z, Wingreen NS. (2014) Enzyme clustering accelerates processing of intermediates through metabolic channeling. Nat Biotechnol. 32: 1011-8. Pubmed

Jean Beltran PM, Cristea IM. (2014) The life cycle and pathogenesis of human cytomegalovirus infection: lessons from proteomics. Expert Rev Proteomics. 11: 697-711. Pubmed

Budayeva HG, Cristea IM. (2014) A mass spectrometry view of stable and transient protein interactions. Adv Exp Med Biol. 806: 263-82. Pubmed

Guise AJ, Mathias RA, Rowland EA, Yu F, Cristea IM. (2014) Probing phosphorylation-dependent protein interactions within functional domains of histone deacetylase 5 (HDAC5). Proteomics. 14: 2156-66. Pubmed

Todd M. Greco, Benjamin A. Diner, and Ileana M. Cristea. (2014) The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology. Annual Review of Virology, Vol. 1: 581-604. [Epub ahead of print]

Li T, Chen J, Cristea IM. (2013) Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion. Cell Host Microbe. 14: 591-9. Pubmed

Miteva YV, Cristea IM, (2014) A proteomic perspective of Sirtuin 6 (SIRT6) phosphorylation and interactions and their dependence on its catalytic activity. Mol Cell Proteomics. 2014 Jan;13(1):168-83. doi: 10.1074/mcp.M113.032847. Epub 2013 Oct 25. PubMed

Tsai YC, Greco TM, Cristea IM, (2014) Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis. Mol Cell Proteomics. 2014 Jan;13(1):73-83. doi: 10.1074/mcp.M113.031377. Epub 2013 Oct 10. PubMed

Li T, Chen, J, Cristea IM, (2013) Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion. Cell Host Microbe. 2013 Nov 13 PubMed

Rowles DL, Terhune SS, Cristea IM. (2013) Discovery of host-viral protein complexes during infection. Methods Mol Biol. 1064: 43-70. Pubmed

Lin AE, Greco TM, Dohner K, Sodeik B, Cristea IM. (2013) A proteomic perspective of inbuilt viral protein regulation: pUL46 viral tegument protein is targeted for degradation by the viral ICP0 protein during HSV-1 infection. Mol Cell Proteomics. Aug 12. [Epub ahead of print]

Guise AJ, Budayeva HG, Diner BA, Cristea IM. (2013) Histone ceacetylases in Herpesvirus replication and virus-stimulated host defense. Viruses. 5: 1607-1632. Pubmed

Kratchmarov R, Kramer T, Greco TM, Taylor MP, Ch'ng TH, Cristea IM, Enquist LW. (2013) Glycoproteins gE and gI are required for efficient KIF1A-dependent anterograde axonal transport of alphaherpesvirus particles in neurons. J Virol. 87: 9431-40. Pubmed

Joshi P, Greco TM, Guise AJ, Luo Y, Yu F, Nesvizhskii AI, Cristea IM. (2013) The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol. 9: 672. Pubmed

Kramer T, Greco TM, Taylor MP, Ambrosini AE, Cristea IM, Enquist LW. (2012) Kinesin-3 mediates axonal sorting and directional transport of alphaherpesvirus particles in neurons. Cell Host Microbe.12: 806-14. Pubmed

Miteva YV, Budayeva HG, Cristea IM. (2013) Proteomics-based methods for discovery, quantification, and validation of protein-protein interactions. Anal Chem. Jan 15;85(2):749-68. doi: 10.1021/ac3033257. Epub 2012 Dec 12. PubMed

Kramer T, Greco TM, Taylor MP, Ambrosini AE, Cristea IM, Enquist LW. Kinesin-3 mediates axonal sorting and directional transport of alphaherpesvirus particles in neurons. (2012) Cell Host Microbe. Dec 13;12(6):806-14. doi: 10.1016/j.chom.2012.10.013. PMID: 23245325 PubMed

Conlon FL, Miteva Y, Kaltenbrun E, Waldron L, Greco TM, Cristea IM. (2012) Immunoisolation of protein complexes from Xenopus. Methods Mol Biol. 917:369-90. doi: 10.1007/978-1-61779-992-1_21. PubMed

Greco TM, Miteva Y, Conlon FL, Cristea IM. (2012) Complementary proteomic analysis of protein complexes. Methods Mol Biol. 917:391-407. doi: 10.1007/978-1-61779-992-1_22.  PubMed

Guise AJ, Greco TM, Zhang IY, Yu F, Cristea IM (2012). Aurora B-dependent regulation of class IIa histone deacetylases by mitotic nuclear localization signal phosphorylation. Mol Cell Proteomics.  Nov;11(11):1220-9. doi: 10.1074/mcp.M112.021030. Epub 2012 Aug 2.  PubMed

Gudleski-O'Regan N, Greco TM, Cristea IM, Shenk T (2012). Increased Expression of LDL Receptor-Related Protein 1 during Human Cytomegalovirus Infection Reduces Virion Cholesterol and Infectivity. Cell Host Microbe 12(1):86-96. PubMed

Li T, Diner BA, Chen J, Cristea IM (2012). Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc Natl Acad Sci USA 109(26):10558-63. PubMed

Youn S, Li T, McCune BT, Edeling MA, Fremont DH, Cristea IM, Diamond MS (2012). Evidence for a genetic and physical interaction between nonstructural proteins NS1 and NS4B that modulates replication of West Nile virus. J Virol 86(13):7360-71. PubMed

Goodarzi H, Najafabadi HS, Oikonomou P, Greco TM, Fish L, Salavati R, Cristea IM, Tavazoie S (2012). Systematic discovery of structural elements governing stability of mammalian messenger RNAs. Nature 485(7397):264-8. PubMed

Sabouri N, McDonald KR, Webb CJ, Cristea IM, Zakian VA (2012). DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. Genes Dev 26(6):581-93. PubMed

Tsai YC, Greco TM, Boonmee A, Miteva Y, Cristea IM (2011). Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Exapnds its Role in RNA Pol I Transcription. Mol Cell Proteomics 11(2):M111.015156. PubMed

Cristea IM, Chait BT (2011). Conjugation of magnetic beads for immunopurification of protein complexes. Cold Spring Harb Protoc 2011(5):534-37. PubMed

Cristea IM, Chait BT (2011). Affinity purification of protein complexes. Cold Spring Harb Protoc 2011(5):538-41. PubMed

Kramer T, Greco TM, Enquist LW, Cristea IM (2011). Proteomic Characterization of Pseudorabies Virus Extracellular Virions.  J Virol 85(13):6427-41. PubMed

Blanco MA, Aleckovic M, Hua Y, Li T, Wei Y, Xu Z, Cristea IM, Kang Y (2011). Identification of Staphylococcal nuclease domain containing 1 (SND1) as a Metadherin-interacting protein with metastasis-promoting functions.  J Biol Chem 286(22):19982-92. PubMed

Dokudovskaya S, Waharte F, Schlessinger A, Pieper U, Devos DP, Cristea IM, Williams R, Salamero J, Chait BT, Sali A, Field MC, Rout MP, Dargemont C (2011). A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics 10(6):M110.006478. PubMed

Cowles CE, Li Y, Semmelhack MF, Cristea IM, Silhavy TJ (2011). The free and bound forms of Lpp occupy distinct subcellular locations in Escherichia coli. Mol Microbiol 79(5):1168-81. PubMed

Bloom J, Cristea IM, Procko AL, Lubkov V, Chait BT, Snyder M, Cross FR (2011). Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes. J Biol Chem 286(7):5434-45. PubMed

Greco TM, Yu F, Guise AJ, Cristea IM (2011). Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Mol Cell Proteomics 10(2):M110.004317. PubMed

Terhune SS, Moorman NJ, Cristea IM, Savaryn JP, Cuevas-Bennett C, Rout MP, Chait BT, Shenk T (2010). Human cytomegalovirus UL28/28 protein interacts with components of the NuRD complex which promote acumulation of immediate-early RNA. PLoS Pathog 6(6):e1000965. PubMed
Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T (2010). Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol 84(15):7803-14. PubMed
Carabetta VJ, Silhavy TJ, Cristea IM (2010). The response regulator SprE (RssB) is required for maintaining PAP I-degradosome association during stationary phase. J Bacteriol 192(14):3713-21. PubMed
Cristea IM, Rozjabek H, Molloy KR, Karki S, White LL, Rice CM, Rout MP, Chait BT, MacDonald MR (2010). Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: a role for G3BP1 and G3BP2 in virus replication. J Virol 84(13):6720-32. PubMed
Carabetta VJ, Li T, Shakya A, Greco TM, Cristea IM (2010). Integrating Lys-N proteolysis and N-terminal guanidination for improved fragmentation and relative quantification of singly-charged ions. JASMS 21(6):1050-60.  PubMed
Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, Boydston EA, Holmes MC, Gregory PD, Greally JM, Rafii S, Yang C, Scambler PJ, Garrick D, Gibbons RJ, Higgs DR, Cristea IM, Urnov FD, Zheng D, Allis CD (2010). Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions. Cell 140(5):678-691. PubMed

Moorman NJ, Sharon-Friling R, Shenk T, Cristea IM (2009). A targeted spatial-temporal proteomic approach implicates multiple cellular trafficking pathways in human cytomegalovirus virion maturation. Mol Cell Proteomics 9(5):851-60. PubMed

Luo Y, Li T, Yu F, Kramer T, Cristea IM (2009). Resolving the composition of protein complexes using a MALDI LTQ Orbitrap. JASMS 21(1):34-46. PubMed 

Selimi F, Cristea IM, Heller E, Chait BT, Heintz N (2009). Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse. PLoS Biol 7: 948-957. PubMed

Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T (2008). Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe 3: 253-262. PubMed

Glavy JS, Krutchinsky A, Cristea IM, Berke IC, Boehmer T, Blobel G, Chait BT (2007). Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Proc Natl Acad Sci USA 104: 3811-3816. PubMed

Warwood S, Mohammed S, Cristea IM, Evans C, Whetton AD, Gaskell SJ (2006). Guanidination chemistry for qualitative and quantitative proteomics. Rapid Commun Mass Spec 20: 3245-3256. PubMed

Cristea IM, Carroll JW, Rout MP, Rice CM, Chait BT, MacDonald MR (2006). Tracking and elucidating alphavirus-host protein interactions. J Biol Chem 281: 30269-30278. PubMed

Wang QJ, Ding Y, Kohtz DS, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N, Yue Z (2006). Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 26: 8057-8068. PubMed

Cristea IM, Williams R, Chait BT, Rout MP (2005). Fluorescent proteins as proteomic probes. Mol Cell Proteomics 4: 1933-1941. PubMed

Cristea IM, Degli Esposti M (2004). Membrane lipids and cell death: an overview. Chem Phys Lipids 129: 133-160. PubMed

Sorice M, Circella A, Cristea IM, Garofalo T, Di Renzo L, Alessandri C, Valesini G, Degli Esposti M (2004). Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis. Cell Death Differ 11: 1133-1145. PubMed

Meneses-lorente G, Guest P, Lawrence J, Muniappa N, Knowles M, Skynner H, Salim K, Cristea I, Mortishire-Smith R, Gaskell SJ, Watt A (2004). A proteomic investigation of drug induced steatosis in rat liver. Chem Res Toxicol 17: 205-212. PubMed 

Cristea IM, Gaskell SJ, Whetton DW (2004). Proteomics techniques and their application to hematology. Blood 103: 3624-3634. PubMed

Degli Esposti M, Cristea IM, Gaskell SJ, Nakao Y, Dive C (2003). Pro-apoptotic Bid binds to monolysocardiolipin, a new molecular connection between mitochondrial membranes and cell death. Cell Death Differ 10: 1300-1309. PubMed

Fairlamb IJS, Dickinson JM, Cristea IM (2001). Influence of palladium(II) complexes on the cycloaddition of α-bromoalkyl ketenes to cyclopentadiene. Tetrahedron 57: 2237.

Fairlamb IJS, Dickinson JM, Cristea IM (2000). Palladium-catalysed [π2a + π2s] of α-bromoalkyl ketenes to cyclopentadiene. Tetrahedron Letters 41: 3739.