Professor of Molecular Biology
Jane Flint is a Professor of Molecular Biology at Princeton University. She became enthralled with science when introduced to the explanatory power of chemistry at age 13, and decided to pursue an undergraduate degree in Biochemistry. After graduate training in the same discipline at University College, London, Dr. Flint began postdoctoral studies at the Cold Spring Harbor Laboratory, New York, and helped develop the first transcriptional map of the human adenovirus DNA genome. She continued to investigate adenoviral gene expression in productively-infected and transformed cells as a postdoctoral fellow with Dr. Phillip Sharp, Massachusetts Institute of Technology, and from 1977, as Assistant Professor of Biochemical Sciences at Princeton University. Dr. Flint served as Associate Chair of that department and Director of the Program in Molecular Biology from 1982 until the Department of Molecular Biology was formed in 1984.
Dr. Flint's research focuses on investigation of the molecular mechanisms by which viral gene products modulate host cell pathways and anti-viral defenses to allow efficient reproduction in normal human cells of adenoviruses, viruses that are widely used in such therapeutic applications as gene transfer and cancer treatment. Dr. Flint's fascination with the marvelous variety in virus-host cell interactions, and her pleasure in writing, spurred her to lead a team of four authors of the popular text "Principles of Virology: Molecular Biology, Pathogenesis and Control". Her service to the scientific community includes membership of various editorial boards and several NIH study sections (including Chair of Biochemistry) and other review panels, and she is currently a member of the Biosafety Working Group of the NIH Recombinant DNA Advisory Committee. Dr. Flint was elected to the American Academy of Microbiology in 2000.