The p53 protein does not facilitate adenovirus type 5 replication in normal human cells.

Citation:

Chahal, Jasdave S, and SJ Flint. “The p53 protein does not facilitate adenovirus type 5 replication in normal human cells.”. J Virol 87.10 (2013): , 87, 10, 6044-6. Web.

Date Published:

2013 May

ISSN:

1098-5514

Abstract:

Although several adenovirus type 5 (Ad5) proteins prevent deleterious consequences of activation of p53, it has been reported that viral replication proceeds more efficiently when human tumor cells produce wild-type compared to mutant p53. We have now exploited RNA interference and lentiviral vectors to achieve essentially complete knockdown of p53 in normal human cells: no effects on the kinetics or efficiency of viral gene expression or production of infectious particles were observed.

DOI:

10.1128/JVI.00129-13

Alternate Journal:

J. Virol.
Last updated on 01/17/2020