Glorund interactions in the regulation of gurken and oskar mRNAs.

Citation:

Kalifa Y, Armenti ST, Gavis ER. Glorund interactions in the regulation of gurken and oskar mRNAs. Dev Biol 2009;326(1):68-74.
Glorund interactions in the regulation of gurken and oskar mRNAs.

Date Published:

2009 Feb 01

ISSN:

1095-564X

Abstract:

Precise temporal and spatial regulation of gene expression during Drosophila oogenesis is essential for patterning the anterior-posterior and dorsal-ventral body axes. Establishment of the anterior-posterior axis requires posterior localization and translational control of both oskar and nanos mRNAs. Establishment of the dorsal-ventral axis depends on the precise restriction of gurken mRNA and protein to the dorsal-anterior corner of the oocyte. We have previously shown that Glorund, the Drosophila hnRNP F/H homolog, contributes to anterior-posterior axis patterning by regulating translation of nanos mRNA, through a direct interaction with its 3' untranslated region. To investigate the pleiotropy of the glorund mutant phenotype, which includes dorsal-ventral and nuclear morphology defects, we searched for proteins that interact with Glorund. Here we show that Glorund is part of a complex containing the hnRNP protein Hrp48 and the splicing factor Half-pint and plays a role both in mRNA localization and nurse cell chromosome organization, probably by regulating alternative splicing of ovarian tumor. We propose that Glorund is a component of multiple protein complexes and functions both as a translational repressor and splicing regulator for anterior-posterior and dorsal-ventral patterning.

DOI:

10.1016/j.ydbio.2008.10.032

Alternate Journal:

Dev. Biol.
Last updated on 10/04/2017