Frederick M. Hughson
Frederick M. Hughson is Professor of Molecular Biology, with an associated appointment in the Department of Chemistry. In 1984, Fred received a B.S. in Molecular Biochemistry and Biophysics from Yale. In 1990, he earned Ph.D. in Biochemistry from Stanford for work on protein folding with Robert L. (Buzz) Baldwin. After postdoctoral work with Don Wiley at Harvard on the x-ray structure of influenza hemagglutinin in its activated, low-pH state, Fred joined the Princeton faculty in 1994. With the exception of a sabbatical at the Medical Research Council’s Laboratory of Molecular Biology in Cambridge UK, Fred has been at Princeton ever since. Current research in the Hughson lab focuses on the multidisciplinary application of diverse tools, but especially x-ray crystallography, to the study of two areas of cell biology – intracellular transport and bacterial cell-cell communication (quorum sensing).
Fred has taught both undergraduate and graduate courses. Since 2010, his primary teaching responsibility has been undergraduate biochemistry, for which he won the President's Award for Distinguished Teaching in 2015. From 2006-2015, Fred served as director of the Princeton-HHMI Undergraduate Science Education Program. Over the years, he has been an NSF Graduate Fellow, a Helen Hay Whitney Postdoctoral Fellow, a Searle Scholar, and a Beckman Young Investigator. Currently, Fred serves on the editorial boards for the journals Science and PLoS Biology. He is a fellow of Whitman College (Princeton) and a life member of Clare Hall (Cambridge UK).
MOLECULAR BIOLOGY 345: BIOCHEMISTRY
Fundamental concepts of biomolecular structure and function are discussed, with an emphasis on principles of thermodynamics, binding and catalysis. A major portion of the course focuses on metabolism and its logic and regulation.