Molecular architecture of the complete COG tethering complex.

Citation:

Ha, J.Y., et al. Molecular architecture of the complete COG tethering complex. Nat Struct Mol Biol 23, 8, 758-60 (2016).

Date Published:

2016 Aug

ISSN:

1545-9985

Abstract:

The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from that of the exocyst complex and appears to be well suited for vesicle capture and fusion.

DOI:

10.1038/nsmb.3263

Alternate Journal:

Nat. Struct. Mol. Biol.