C, Liverani, and et al. “A biomimetic 3D model of hypoxia-driven cancer progression.”. Science Reports, a Nature Research Journal 9 (2019). Web. Pub Med
of the Society., Board Members Metastasis Research. “The importance of developing therapies targeting the biological spectrum of metastatic disease.”. Clinical & Experimental Metastasis 36 (2019). Web. Pub Med
M, Esposito, and et al. “Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis.”. Nat Cell Biol 21 (2019). Web. Pub Med
Aiello NM, Kang Y.Context-dependent EMT programs in cancer metastasis.”. Journal of Experimental Medicine (2019). Web. Pub Med
Lu, S, and et al. “Racial profiling harms science.”. Science 363 (2019). Web. Pub Med
T, Celià-Terrassa. “Author Correction: Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability.”. 10 (2019). Web. Pub MedAbstract
The original version of this Article contained an error in the spelling of the author Daniel D. Liu, which was incorrectly given as Daniel Liu. This has now been corrected in both the PDF and HTML versions of the Article.
H, Zhang, and et al. “CD44 splice isoform switching determines breast cancer stem cell state.”. Genes Dev 33 (2019). Web. Pub Med
Monsivais D,, et al.Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma.”. Proc Natl Acad Sci 116 (2019). Web. Pub Med
W, Zhuo, and et al. “Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS”. Gastroenterology 156.3 (2019). Web. Pub Med
M, Shen, and “Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.”. Cancer Cell 35 (2019). Web. Pub Med
T, Celià-Terrassa, et al.Hysteresis control of epithelial-mesenchymal transition dynamics conveys a distinct program with enhanced metastatic ability.”. Nat Commununications 9 (2018). Web. Pub Med
Shen M, Kang Y.Complex interplay between tumor microenvironment and cancer therapy.”. Frontiers of Medicine 12 (2018). Web. Pub Med
Celià-Terrassa T, Kang Y.Metastatic niche functions and therapeutic opportunities.”. Nat Cell Biol 20 (2018). Web. Pub Med
R, Chakrabarti, et al.Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche.”. Science 360.6396 (2018). Web. Pub Med
Jin, Lingtao, et al.The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer”. Mol Cell 69.1 (2018): , 69, 1, 87-99.e7. Web. Pub MedAbstract
Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer, but the development of targeted agents is in its infancy. Here we report that a glutaminolytic enzyme, glutamate dehydrogenase 1 (GDH1), upregulated upon detachment via pleomorphic adenoma gene 1 (PLAG1), provides anti-anoikis and pro-metastatic signals in LKB1-deficient lung cancer. Mechanistically, the GDH1 product α-KG activates CamKK2 by enhancing its substrate AMPK binding, which contributes to energy production that confers anoikis resistance. The effect of GDH1 on AMPK is evident in LKB1-deficient lung cancer, where AMPK activation predominantly depends on CamKK2. Targeting GDH1 with R162 attenuated tumor metastasis in patient-derived xenograft model and correlation studies in lung cancer patients further validated the clinical relevance of our finding. Our study provides insight into the molecular mechanism by which GDH1-mediated metabolic reprogramming of glutaminolysis mediates lung cancer metastasis and offers a therapeutic strategy for patients with LKB1-deficient lung cancer.
Oslund, Rob C, et al.Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate”. Nat Chem Biol 13.10 (2017): , 13, 10, 1081-1087. Web.Abstract
Lower glycolysis involves a series of reversible reactions, which interconvert intermediates that also feed anabolic pathways. 3-phosphoglycerate (3-PG) is an abundant lower glycolytic intermediate that feeds serine biosynthesis via the enzyme phosphoglycerate dehydrogenase, which is genomically amplified in several cancers. Phosphoglycerate mutase 1 (PGAM1) catalyzes the isomerization of 3-PG into the downstream glycolytic intermediate 2-phosphoglycerate (2-PG). PGAM1 needs to be histidine phosphorylated to become catalytically active. We show that the primary PGAM1 histidine phosphate donor is 2,3-bisphosphoglycerate (2,3-BPG), which is made from the glycolytic intermediate 1,3-bisphosphoglycerate (1,3-BPG) by bisphosphoglycerate mutase (BPGM). When BPGM is knocked out, 1,3-BPG can directly phosphorylate PGAM1. In this case, PGAM1 phosphorylation and activity are decreased, but nevertheless sufficient to maintain normal glycolytic flux and cellular growth rate. 3-PG, however, accumulates, leading to increased serine synthesis. Thus, one biological function of BPGM is controlling glycolytic intermediate levels and thereby serine biosynthetic flux.
Peng, Jia, and Yibin Kang. “The Bony Side of Endothelial Cells in Prostate Cancer”. Dev Cell 41.5 (2017): , 41, 5, 451-452. Web.Abstract
Prostate cancer bone metastases are primarily osteoblastic, but the source of bone-forming cells in these lesions remains poorly defined. In this issue of Developmental Cell, Lin et al. (2017) demonstrate that tumor-associated endothelial cells can give rise to osteoblasts in prostate cancer through endothelial-to-osteoblast (EC-to-OSB) conversion.
Alečković, Maša, et al.Identification of Nidogen 1 as a lung metastasis protein through secretome analysis”. Genes Dev 31.14 (2017): , 31, 14, 1439-1455. Web.Abstract
Secreted proteins play crucial roles in mediating tumor-stroma interactions during metastasis of cancer to different target organs. To comprehensively profile secreted proteins involved in lung metastasis, we applied quantitative mass spectrometry-based proteomics and identified 392 breast cancer-derived and 302 melanoma-derived proteins secreted from highly lung metastatic cells. The cancer-specific lung metastasis secretome signatures (LMSSs) displayed significant prognostic value in multiple cancer clinical data sets. Moreover, we observed a significant overlap of enriched pathways between the LMSSs of breast cancer and melanoma despite an overall small overlap of specific proteins, suggesting that common biological processes are executed by different proteins to enable the two cancer types to metastasize to the lung. Among the novel candidate lung metastasis proteins, Nidogen 1 (NID1) was confirmed to promote lung metastasis of breast cancer and melanoma, and its expression is correlated with poor clinical outcomes. In vitro functional analysis further revealed multiple prometastatic functions of NID1, including enhancing cancer cell migration and invasion, promoting adhesion to the endothelium and disrupting its integrity, and improving vascular tube formation capacity. As a secreted prometastatic protein, NID1 may be developed as a new biomarker for disease progression and therapeutic target in breast cancer and melanoma.
Celià-Terrassa, Toni, et al.Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis”. Nat Cell Biol 19.6 (2017): , 19, 6, 711-723. Web.Abstract
Tumour-initiating cells, or cancer stem cells (CSCs), possess stem-cell-like properties observed in normal adult tissue stem cells. Normal and cancerous stem cells may therefore share regulatory mechanisms for maintaining self-renewing capacity and resisting differentiation elicited by cell-intrinsic or microenvironmental cues. Here, we show that miR-199a promotes stem cell properties in mammary stem cells and breast CSCs by directly repressing nuclear receptor corepressor LCOR, which primes interferon (IFN) responses. Elevated miR-199a expression in stem-cell-enriched populations protects normal and malignant stem-like cells from differentiation and senescence induced by IFNs that are produced by epithelial and immune cells in the mammary gland. Importantly, the miR-199a-LCOR-IFN axis is activated in poorly differentiated ERbreast tumours, functionally promotes tumour initiation and metastasis, and is associated with poor clinical outcome. Our study therefore reveals a common mechanism shared by normal and malignant stem cells to protect them from suppressive immune cytokine signalling.
Yang, Mu, et al.Short-term and long-term clinical outcomes of uncommon types of invasive breast cancer”. Histopathology 71.6 (2017): , 71, 6, 874-886. Web.Abstract
AIMS: Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) are predominant and well-documented types of invasive breast cancer (IBC). We investigated the clinical outcomes of other types of IBC (i.e. uncommon IBC), which collectively account for Σ20% of all IBC cases, as these are largely unknown. METHODS AND RESULTS: We identified all IBC cases diagnosed in 2004-2006 (n = 159 293) and 2010-2011 (n = 118 822) from the Surveillance, Epidemiology and End Results (SEER) database. Uncommon IBCs included mixed IDC and ILC (MDLC), IDC mixed with other types of carcinoma, ILC mixed with other types of carcinoma, and other-type breast cancers (OCs). We estimated overall survival (OS) and cancer-specific survival in multivariate regression models. As compared with IDC, MDLC was associated with an increased OS [adjusted hazard ratio (aHR) = 0.92, P < 0.001 at Σ10 years of follow-up; aHR = 0.88, P = 0.01 at Σ4 years of follow-up], whereas OCs were associated with a decreased OS (aHR = 1.06, P = 0.005 at Σ10 years of follow-up; aHR = 1.23, P < 0.001 at Σ4 years of follow-up). Women with other uncommon IBCs had an OS similar to those with IDC. Heterogeneity in survival was observed for some subtypes of OC, with better OS for women with MDLC and tubular carcinoma. Radiotherapy extended OS for all types of IBC in older women (≥50 years). For younger women (<50 years), radiotherapy improved OS in women with IDC, but not in those with ILC or uncommon IBC. Radiotherapy did not change cancer-specific survival of younger women with any IBC. CONCLUSIONS: Uncommon IBCs have distinct patterns of prognosis and survival. The effectiveness of radiotherapy in women with uncommon IBC may differ by age. The underlying mechanisms warrant further studies.