β-Spectrin regulates the hippo signaling pathway and modulates the basal actin network.

Citation:

Wong, Kenneth Kin Lam, et al. “β-Spectrin regulates the hippo signaling pathway and modulates the basal actin network.”. J Biol Chem 290.10 (2015): , 290, 10, 6397-407. Web.

Date Published:

2015 Mar 06

ISSN:

1083-351X

Abstract:

Emerging evidence suggests functional regulation of the Hippo pathway by the actin cytoskeleton, although the detailed molecular mechanism remains incomplete. In a genetic screen, we identified a requirement for β-Spectrin in the posterior follicle cells for the oocyte repolarization process during Drosophila mid-oogenesis. β-spectrin mutations lead to loss of Hippo signaling activity in the follicle cells. A similar reduction of Hippo signaling activity was observed after β-Spectrin knockdown in mammalian cells. We further demonstrated that β-spectrin mutations disrupt the basal actin network in follicle cells. The abnormal stress fiber-like actin structure on the basal side of follicle cells provides a likely link between the β-spectrin mutations and the loss of the Hippo signaling activity phenotype.

DOI:

10.1074/jbc.M114.629493

Alternate Journal:

J. Biol. Chem.