Cradle of evil: osteogenic niche for early bone metastasis.

Citation:

Zheng, Hanqiu, and Yibin Kang. “Cradle of evil: osteogenic niche for early bone metastasis.”. Cancer Cell 27.2 (2015): , 27, 2, 153-5. Web.

Date Published:

2015 Feb 09

ISSN:

1878-3686

Abstract:

Bone metastasis often emerges long after the initial dissemination of cancer cells. In this issue of Cancer Cell, Wang and colleagues demonstrate that disseminated breast cancer cells engage osteogenic niches in the bone through heterotypic adherins junctions. This interaction activates mTOR signaling in cancer cells and supports their expansion to micrometastases.

DOI:

10.1016/j.ccell.2015.01.006

Alternate Journal:

Cancer Cell