Lnc-ing ROR1-HER3 and Hippo signalling in metastasis.


Zhuo, Wei, and Yibin Kang. “Lnc-ing ROR1-HER3 and Hippo signalling in metastasis.”. Nat Cell Biol 19.2 (2017): , 19, 2, 81-83. Web.

Date Published:

2017 Jan 31


Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

Last updated on 12/12/2017