Lnc-ing ROR1-HER3 and Hippo signalling in metastasis.

Citation:

Zhuo, Wei, and Yibin Kang. “Lnc-ing ROR1-HER3 and Hippo signalling in metastasis.”. Nat Cell Biol 19.2 (2017): , 19, 2, 81-83. Web.

Date Published:

2017 Jan 31

Abstract:

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

Last updated on 12/12/2017