Microbial metabolite as icebreaker for immunotherapy

Citation:

Tang, Yong, and Yibin Kang. “Microbial metabolite as icebreaker for immunotherapy”. Cell Metab 34.4 (2022): , 34, 4, 506-507. Web.

Date Published:

2022 04 05

ISSN:

1932-7420

Abstract:

Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8 T cell-mediated antitumor immunity by inducing pyroptosis in tumor cells, enhancing the efficacy of immunotherapy in TNBC (Wang et al., 2022).

DOI:

10.1016/j.cmet.2022.03.003

Alternate Journal:

Cell Metab