MiR-215 modulates gastric cancer cell proliferation by targeting RB1.

Citation:

Deng, Yujie, et al. “MiR-215 modulates gastric cancer cell proliferation by targeting RB1.”. Cancer Lett 342.1 (2014): , 342, 1, 27-35. Web.

Date Published:

2014 Jan 01

ISSN:

1872-7980

Abstract:

Growing evidence indicates that miRNAs play critical roles in tumorigenesis and cancer progression. Here, we report that miR-215 is significantly up-regulated in gastric cancer tissues from either gastrectomy or gastroscopy. Receiver Operator Characteristic (ROC) curve analysis indicated that miR-215 may be a candidate biomarker for gastric cancer diagnosis. Inhibition of miR-215 significantly suppressed gastric cancer cell proliferation possibly via G1 arrest. Further analyses indicated that miR-215 was able to target retinoblastoma tumor-suppressor gene 1 (RB1) through its 3'-UTR in gastric cancer cells. These data suggest that frequently up-regulated miR-215 in gastric cancer may influence cell proliferation by targeting RB1.

DOI:

10.1016/j.canlet.2013.08.033

Alternate Journal:

Cancer Lett.