Mouse genomic screen reveals novel host regulator of metastasis

Citation:

Celià-Terrassa, Toni, and Yibin Kang. “Mouse genomic screen reveals novel host regulator of metastasis”. Genome Biol 18.1 (2017): , 18, 1, 31. Web.

Date Published:

2017 Feb 16

Abstract:

Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.

Last updated on 12/12/2017