A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β.

Author
Wenyang Li, Yibin Kang
Publication Year
2014

Type

Journal Article
Abstract

TGF-β signaling promotes metastasis by controlling the expression of downstream target genes. In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-β-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.

Keywords
Animals, Humans, RNA, Long Noncoding, Male, Transforming Growth Factor beta, Liver Neoplasms, Carcinoma, Hepatocellular
Journal
Cancer Cell
Volume
25
Issue
5
Pages
557-9
Date Published
05/2014
ISSN Number
1878-3686
DOI
10.1016/j.ccr.2014.04.014
Alternate Journal
Cancer Cell
PMID
24823634