A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β.

Citation:

Li, Wenyang, and Yibin Kang. “A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β.”. Cancer Cell 25.5 (2014): , 25, 5, 557-9. Web.

Date Published:

2014 May 12

ISSN:

1878-3686

Abstract:

TGF-β signaling promotes metastasis by controlling the expression of downstream target genes. In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-β-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.

DOI:

10.1016/j.ccr.2014.04.014

Alternate Journal:

Cancer Cell