A one-two punch of miR-126/126* against metastasis.

Citation:

Ren, Guangwen, and Yibin Kang. “A one-two punch of miR-126/126* against metastasis.”. Nat Cell Biol 15.3 (2013): , 15, 3, 231-3. Web.

Date Published:

2013 Mar

ISSN:

1476-4679

Abstract:

MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.

DOI:

10.1038/ncb2703

Alternate Journal:

Nat. Cell Biol.