Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis.

Citation:

Alečković, Maša, and Yibin Kang. “Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis.”. Cancer Cell 28.5 (2015): , 28, 5, 554-6. Web.

Date Published:

2015 Nov 09

ISSN:

1878-3686

Abstract:

Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.

DOI:

10.1016/j.ccell.2015.10.010

Alternate Journal:

Cancer Cell