Recent Publications

Submitted
Beltrán-Sánchez H, Goldman N, Pebley AR, Morales JF. Calloused Hands, Shorter Life? Occupation and Older Age Survival in Mexico. Demographic Research. Submitted.
Andrasfay T, Goldman N. Birth Outcomes of Foreign and US-born Black Women Converge in One Generation. Submitted.
Gaydosh L, Belsky D, Glei D, Goldman N. Testing proposed quanitifications of biological aging in Taiwanese older adults. The Journals of Gerontology: Series A. Submitted.
Pebley A, Goldman N, Andrasfay T, Pratt B. Harsher Work Conditions, Poorer Physical Function for Latinos in the US?. Submitted.
Verissimo J, Rugg MD, Pullman MY, et al. Education May Help Counter Declarative Memory Declines in Aging, Especially for Women. Submitted.
Forthcoming
Corman JC, Glei DA, Goldman N, Weinstein M. Social Environment and Biomarkers of Aging Study. Encyclopedia of Gerontology and Population Aging. Forthcoming.
Glei DA, Goldman N, Weinstein M. Health as Reflected by Biomarkers in Older Populations. In: Demographic Studies on Survival and Health. Springer Dordrecht ; Forthcoming.
2018
Todd M, Schneper L, Vasunilashorn S, et al. Apolipoprotein E, Cognitive Function, and Cognitive Decline among Older Taiwanese Adults. PLOS ONE. 2018. Publisher's Version
Goldman N, Glei DA, Weinstein M. Declining Mental Health among Disadvantaged Americans. Proceedings of the National Academy of Sciences. 2018;115 :7290-7295. Publisher's VersionAbstract
Although there is little dispute about the impact of the US opioid epidemic on recent mortality, there is less consensus about whether trends reflect increasing despair among American adults. The issue is complicated by the absence of established scales or definitions of despair as well as a paucity of studies examining changes in psychological health, especially well-being, since the 1990s. We contribute evidence using two cross-sectional waves of the Midlife in the United States (MIDUS) study to assess changes in measures of psychological distress and well-being. These measures capture negative emotions such as sadness, hopelessness, and worthlessness, and positive emotions such as happiness, fulfillment, and life satisfaction. Most of the measures reveal increasing distress and decreasing well-being across the age span for those of low relative socioeconomic position, in contrast to little decline or modest improvement for persons of high relative position.
Glei DA, Goldman N, Ryff CD, Weinstein M. Can We Determine Whether Physical Limitations Are More Prevalent in the US than in Countries with Comparable Life Expectancy?. Social Science & Medicine - Population Health. 2018;3 :808-813. Publisher's VersionAbstract
We evaluate the variability in estimates of self-reported physical limitations by age across four nationally representative surveys in the US. We consider its implications for determining whether, as previous literature suggests, the US estimates reveal limitations at an earlier age than in three countries with similar life expectancy: England, Taiwan, and Costa Rica. Based on cross-sectional data from seven population-based surveys, we use local mean smoothing to plot self-reported limitations by age for each of four physical tasks for each survey, stratified by sex. We find substantial variation in the estimates in the US across four nationally-representative surveys. For example, one US survey suggests that American women experience a walking limitation 15 years earlier than their Costa Rican counterparts, while another US survey implies that Americans have a 4-year advantage. Differences in mode of survey may account for higher prevalence of limitations in the one survey that used a self-administered mail-in questionnaire than in the other surveys that used in-person or telephone interviews. Yet, even among US surveys that used the same mode, there is still so much variability in estimates that we cannot conclude whether Americans have better or worse function than their counterparts in the other countries. Seemingly minor differences in question wording and response categories may account for the remaining inconsistency. If minor differences in question wording can result in such extensive variation in the estimates within a given population, then lack of comparability is likely to be an even greater problem when examining results across countries that do not share the same language or culture. Despite the potential utility of self-reported physical function within a survey sample, our findings imply that absolute estimates of population-level prevalence of self-reported physical limitations are unlikely to be strictly comparable across countries—or even across surveys within the same population.
Glei DA, Goldman N, Weinstein M. The Educational Gradient in Physiological Dysregulation: A Cross-Country Investigation. In: Oxford Handbook of Integrative Health Science. Oxford University Press ; 2018.
Glei DA, Goldman N, Weinstein M. Perception Has Its Own Reality: Subjective Versus Objective Measures of Economic Distress. Population and Development Review. 2018;44 (4) :695-722.Abstract
There is no doubt that economic inequality in the US has increased over the last several decades (Piketty, Saez, and Zucm 2016; Congressional Budget Office 2013). Diminished labor market opportunities and the ensuing decline in (inflation‐adjusted) economic fortunes for the least educated Americans have been blamed for initiating a cascade of consequences culminating in rising mortality related to drugs, alcohol, and suicide (Case and Deaton 20172015)—collectively referred to as “deaths of despair” (Khazan 2015; Case 2015; Monnat 2016). The health effects are evident in overall mortality as well: socioeconomic disparities in life expectancy have widened dramatically over this period (Chetty et al. 2016b; Bosworth, Burtless, and Zhang 2016), particularly among non‐Latino whites (Olshansky et al. 2012; Sasson 2016). Beyond its effects on health, inequality1 can have far‐reaching consequences for society as a whole, for example, by compromising social trust and cohesion and jeopardizing the effectiveness of social institutions (Kawachi and Berkman 2000; Kawachi et al. 1997). Indeed, arguments related to growing inequality have been invoked to explain many of the worrisome trends not only in mortality, but in a broader range of health outcomes, as well as social and political phenomena.
217_a_glei.et_.al_.2018.pdr_.economicdistress-perceived_vs._objective.pdf
Pliatsikas C, Verissimo J, Babcock L, et al. General Working Memory in Older Adults Declines with Age, but is Modulated by Sex and Education. Quarterly Journal of Experimental Psychology. 2018. Publisher's VersionAbstract
Working memory (WM), which underlies the temporary storage and manipulation of information, is critical for multiple aspects of cognition and everyday life. Nevertheless, research examining WM specifically in older adults remains limited, despite the global rapid increase in human life expectancy. We examined WM in a large sample (N=754) of healthy older adults (aged 58-89) in a non-Western population (Chinese speakers) in Taiwan, on a digit n-back task. We tested the influence not only of age itself and of load (1-back vs. 2-back), but also effects of both sex and education, which have been shown to modulate WM abilities. Mixed-effects regression revealed that, within older adulthood, age negatively impacted WM abilities (with linear, not nonlinear, effects), as did load (worse performance at 2-back). In contrast, education level was positively associated with WM. Moreover, both age and education interacted with sex. With increasing age, males showed a steeper WM decline than females; with increasing education, females showed greater WM gains than males. Together with other findings, the evidence suggests that age, sex, and education all impact WM in older adults, but interact in particular ways. The results have both basic research and translational implications, and are consistent with particular benefits from increased education for women.
Downer B, Gonzalez-Gonzalez C, Goldman N, Pebley AR, Wong R. The Effect of Adult Children Living in the United States on the Likelihood of Cognitive Impairment for Older Parents Living in Mexico. Ethnicity & Health. 2018;23 :57-71. Publisher's VersionAbstract
The increased risk for poor physical and mental health outcomes for older parents in Mexico who have an adult child living in the United States may contribute to an increased risk for cognitive impairment in this population. The objective of this study was to examine if older adults in Mexico who have one or more adult children living in the United States are more or less likely to develop cognitive impairment over an 11-year period compared to older adults who do not have any adult children living in the United States.
Culverhouse R, et al. Collaborative Meta-analysis Finds No Evidence of a Strong Interaction Between Stress and 5-HTTLPR Genotype Contributing to the Development of Depression. Molecular Psychiatry. 2018;23 :133-142. Publisher's VersionAbstract
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research and controversy since first proposed in 2003. Multiple meta-analyses combining results from heterogeneous analyses have not settled the issue. To determine the magnitude of the interaction and the conditions under which it might be observed, we performed new analyses on 31 data sets containing 38 802 European ancestry subjects genotyped for 5-HTTLPR and assessed for depression and childhood maltreatment or other stressful life events, and meta-analysed the results. Analyses targeted two stressors (narrow, broad) and two depression outcomes (current, lifetime). All groups that published on this topic prior to the initiation of our study and met the assessment and sample size criteria were invited to participate. Additional groups, identified by consortium members or self-identified in response to our protocol (published prior to the start of analysis) with qualifying unpublished data, were also invited to participate. A uniform data analysis script implementing the protocol was executed by each of the consortium members. Our findings do not support the interaction hypothesis. We found no subgroups or variable definitions for which an interaction between stress and 5-HTTLPR genotype was statistically significant. In contrast, our findings for the main effects of life stressors (strong risk factor) and 5-HTTLPR genotype (no impact on risk) are strikingly consistent across our contributing studies, the original study reporting the interaction and subsequent meta-analyses. Our conclusion is that if an interaction exists in which the S allele of 5-HTTLPR increases risk of depression only in stressed individuals, then it is not broadly generalisable, but must be of modest effect size and only observable in limited situations.
Glei DA, Goldman N, Ryff CD, Weinstein M. Physical Function in US Older Adults Compared With Other Populations: A Multinational Study. Journal of Aging and Health. 2018 :1-18. Publisher's VersionAbstract
We compare physical performance from three U.S. national surveys and nationally representative surveys in England, Taiwan, and Costa Rica. Method: For each performance test, we use local mean smoothing to plot the age profiles by sex and survey wave and then fit a linear regression model to the pooled data, separately by sex, to test for significant differences across surveys controlling for age and height. Results: Age profiles of performance vary across U.S. surveys, but levels of lung function (peak expiratory flow) and handgrip strength in the United States are as high as they are in the other three countries. Americans also perform as well on the chair stand test as the English and Costa Ricans, if not better, but exhibit slower gait speed than the English at most ages. Discussion: With the exception of walking speed, we find little evidence that older Americans have worse physical performance than their peers.
2017
Lee C, Glei DA, Goldman N, Weinstein M. Children's Education and Parents' Trajectories of Depressive Symptoms. Journal of Health and Social Behavior. 2017;58 :86-101. Publisher's VersionAbstract
Using five waves of the Taiwanese Longitudinal Study of Aging (1996–2011), we investigate (1) the association between family members’ education and the age trajectories of individuals’ depressive symptoms and (2) gender differences in those relationships. Our examination is guided by several theoretical frameworks, including social capital, social control, age as leveler, and resource substitution. Nested models show that having a more educated father is associated with lower depressive symptoms, but the relationship disappears after controlling for respondent’s education. Including spouse’s education attenuates the coefficient for respondent’s education. A similar pattern appears when children’s education is added to the model. Among all the family members, children’s education has the strongest association with depressive symptoms, with a similar magnitude for both genders, although its strength gradually weakens as respondents age. Our findings suggest the importance of the transfer of resources from children to parents and how it may affect mental health at older ages.
Goldman N, Glei DA, Weinstein M. The Best Predictors of Survival: Do They Vary by Age, Sex, and Race?. Population and Development Review. 2017;43 :541-560. Publisher's VersionAbstract
We consider a broad set of variables used by social scientists and clinicians to identify the leading predictors of five‐year survival among American adults. We address a question not considered in earlier research: Do the strongest predictors of survival vary by age, sex or race/ethnicity? The analysis uses hazard models with 30 well‐established predictors to examine five‐year survival in the National Health and Nutrition Examination Survey. We find that the simple measure of self‐assessed health and self‐reported measures of functional ability and disability are the strongest predictors in all demographic groups, and are generally ranked considerably higher than biomarkers. Among the biomarkers, serum albumin is highly ranked in most demographic groups, whereas clinical measures of cardiovascular and metabolic function are consistently among the weakest predictors. Despite these similarities, there is substantial variation in the leading predictors across demographic groups, most notably by race and ethnicity
Beltrán-Sánchez H, Pebley A, Goldman N. Links Between Primary Occupation and Functional Limitations among Older Adults in Mexico. Social Science and Medicine - Population Health. 2017;3: : 382-392. Publisher's VersionAbstract
Social inequalities in health and disability are often attributed to differences in childhood adversity, access to care, health behavior, residential environments, stress, and the psychosocial aspects of work environments. Yet, disadvantaged people are also more likely to hold jobs requiring heavy physical labor, repetitive movement, ergonomic strain, and safety hazards. We investigate the role of physical work conditions in contributing to social inequality in mobility among older adults in Mexico, using data from the Mexican Health and Aging Survey (MHAS) and an innovative statistical modeling approach. We use data on categories of primary adult occupation to serve as proxies for jobs with more or less demanding physical work requirements. Our results show that more physically demanding jobs are associated with mobility limitations at older ages, even when we control for age and sex. Inclusion of job categories attenuates the effects of education and wealth on mobility limitations, suggesting that physical work conditions account for at least part of the socioeconomic differentials in mobility limitations in Mexico.

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