Congratulations to Stephanie and Glen for receiving the pre-doctoral and post-doctoral New Jersey Commision for Cancer Research Fellowhsip! These fellowships will aid them in understanding HBV species tropism and the interplay between HBV and HIV co-infections. We're excited to see the work you accomplish!
Big welcome to Heidi Temple '24 and Emily Shoeman '23 for joining our lab! Along with Olivia Sakaguchi '23, they will be working towards their senior theses by conducting summer research. Summer is a great time to go full steam ahead in our research and they will be able to learn from their mentors as well as other in the lab as they embark on their research projects. We wish you luck and are happy to have you as part of our lab!
At the TRR179 conference discussing the elimination and persistence of hepatitis virus infections in Freiburg, Germany, Alex delivered a talk titled, "Mechanistic insights into structure and function of hepatitis E virus ORF1 protein". This work probes the function of ORF1, which has been a somewhat controversial debate in the field. This work seeks to elucidate the actual function(s) of the protein in order to provide a better understanding of the HEV infection process.
Congratulations to our 2022 seniors, Daniel, Brian, Debby, Mansi, and Maricar! You all did a fantastic job working on your senior theses, from probing the effects of methylation on liver transcriptomics to uncovering species barriers in HBV infections. We will miss you all very much and wish you good luck on all your future endeavors!
We had the best time celebrating Saori and her future baby, Soh! We're all thrilled for you to welcome your new baby boy into the world and we hope this baby shower showed you our excitement. We'll miss you as you go on maternity leave but we can't wait to see you again with your bundle of joy! Congrats to you and Tomo!
The Ploss lab is delighted to welcome Dr. Glenn Hogan as our newest post doc! Glen received a BPharm degree in 2014 from University College Cork, Ireland and an MPharm degree in 2015 from the Royal College of Surgeons. After completing an internship in pharmacy at University Hospital Waterford and working as Assistant Research Coordinator at St. Vincent’s University Hospital, he received his PhD from UCC, Ireland for his research on probiotic bacterial trafficking to tumors in the hopes of detecting and treating cancer. We’re excited to have Glen join us and excited to see his work here!
The 2021 Annual Molecular Biology Departmental Retreat was held this past weekend at Princeton and we were happy to have three of our lab members present their work!
Robbie gave an oral presentation on “Multi-pathway innate immunity antagonism by Hepatitis E virus ORF1 protein”, Saori presented a poster entitled “Profiling the SARS-CoV2 spike protein interactome using proximity labeling”, and Tomo presented a poster titled “Generation and characterization of genetically and antigenically diverse infectious clones of dengue virus (DENV) serotypes 1-4”.
We all enjoyed learning about their work and the research done by all the labs in our department! We also want to thank the Molecular Biology department and Terry MacFarland for doing preparing a wonderful event!
This last week Alex, Wei, Stephanie, and Yongzhen attended the HBV International meeting in Toronto, Canada! Alex presided as session chair on advances in models for HBV, Wei presented a poster entitled “Mechanistic dissection of rcDNA to cccDNA conversion in murine cells”, Stephanie presented a poster titled “Mathematical modeling of early hepatitis D virus kinetics in hNTCP transgenic mice”, and Yongzhen presented a poster entitled “Construction and characterization of infectious clones derived from hepatitis B virus infected patients”. They had an awesome time meeting with other HBV scientists in person or virtually and enjoyed all that Toronto has to offer!
The Ploss lab is excited to welcome SEVEN new undergrads to our ranks!
Already diving in for some summer research are rising seniors Debby Park ‘22, Daniel Beard ‘22, and Mansi Totwani ‘22. It’s been great having their energy in lab and to see how quickly they’re learning the ropes!
Their mentors also have some very nice things to say about them. Stephanie, who’s working with Mansi, says “I’m really enjoying running around with my chickadee and showing her how to become a virus queen!” Yongzhen, who works with Debby, reports that “she is excited after getting her positive cells!” And according to Keith, “Daniel has got some beautiful qPCR results!”
Come September, we’ll also be joined by Maricar Almeda ‘22, Olivia Sakaguchi ‘23, Christine Nguyen ‘23, and Brian Li ’24. See you all soon!
Look at those worker bees getting stuck into their summer research! Lab life feels like it’s gradually getting back to normal!
Congratulations and farewell to our graduating seniors, Emma Guare ‘21 and Vrinda Madan ‘21! Despite a challenging year of COVID restrictions, these two superstars went above and beyond to complete their senior theses and contribute remotely to ongoing research in the lab. It comes as no surprise that both these ladies are preparing for exciting new adventures in the fall. Emma will be attending Penn State College of Medicine and Vrinda will be attending Johns Hopkins School of Medicine!
We’ll all miss you both very much, and we thank you both for your perseverance, adaptability and hard work. Good luck with your next steps!
Images from Princeton University’s Virtual Class Day, featuring some of their work in the Ploss lab!