Hepatocarcinogenesis associated with hepatitis B, delta and C viruses.


Shirvani-Dastgerdi, Elham, Robert E Schwartz, and Alexander Ploss. “Hepatocarcinogenesis associated with hepatitis B, delta and C viruses.”. Curr Opin Virol 20 (2016): , 20, 1-10. Web.

Date Published:

2016 Oct




Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.



Alternate Journal:

Curr Opin Virol