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A mouse model for HIV-1 entry.

Citation:

Pietzsch, John, et al. “A mouse model for HIV-1 entry.”. Proc Natl Acad Sci U S A 109.39 (2012): , 109, 39, 15859-64. Web.

Date Published:

2012 Sep 25

ISSN:

1091-6490

Abstract:

Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically humanized mouse model that incorporates a luciferase reporter for rapid quantitation of HIV entry. An antibody's ability to block viral entry in this in vivo model is a function of its bioavailability, direct neutralizing activity, and effector functions.

DOI:

10.1073/pnas.1213409109

Alternate Journal:

Proc. Natl. Acad. Sci. U.S.A.