Joshua D. Rabinowitz
EDUCATION
Stanford University
M.D., 2001
Ph.D. in Biophysics, 1999
University of North Carolina at Chapel Hill
B.A. with Highest Honors in Mathematics, 1994
B.A. in Chemistry, 1994
RESEARCH POSITIONS
Princeton University
Department of Chemistry & Lewis-Sigler Institute for Integrative Genomics
Professor, 2011–present
Associate Professor, 2009–2011
Assistant Professor, 2004–2009
Department of Molecular Biology
Associated Faculty, 2005–present
Rutgers Cancer Institute of New Jersey, Member, 2008-
Alexza Pharmaceuticals
Co-founder and Vice President, Research, 2000–2004
- Accelerating onset of drug action through thermally generated aerosols
HONORS, AWARDS, AND FELLOWSHIPS
NIH Pioneer Award, 2016
Agilent Thought Leader Award, 2013
Kavli Frontiers of Science Scholar, Kavli Foundation and National Academy of Sciences, 2008
CAREER Award, National Science Foundation, 2007–2013
Beckman Young Investigator Award, Arnold and Mabel Beckman Foundation, 2005–2009
Medical Scientist Training Program (MSTP) Trainee, National Institutes of Health, 1994–2001
Churchill Fellow (Declined), 1994
Barry M. Goldwater Scholar, Federal Excellence in Education Foundation, U.S. Federal Government, 1993–1994
President, Phi Beta Kappa, University of North Carolina, 1993–1994
Herbert Worth Jackson Scholar, University of North Carolina Honors Program, 1990–1994
PUBLICATIONS
See publications tab.
RECENT INVITED TALKS
University of California-Sacramento, Comprehensive Cancer Center (2017)
University of California-Davis, West Coast Metabolomics Center (2017)
NYU, Center for Genomics and Systems Biology Symposium (2017)
CSHL, Mechanisms of Metabolic Signaling Meeting (2017)
University of CO, Denver, Dept. of Biochemistry & Molecular Genetics (2017)
Keystone Symposium on Tumor Metabolism (2017)
CSHL, Chemistry & Metabolism Meeting (2017)
University of California-Los Angeles, David Geffen School of Medicine (2016)
New York Academy of Science (2016)
Rutgers University, Boxer Lecture (2016)
American Association for Cancer Research, New Orleans (2016)
Parker Institute for Cancer Immunotherapy Retreat (2016)
New Frontiers in Understanding Tumor Metabolism/Immunometabolism
in Immune Function & Inflammatory Disease, Banff, Alberta (2016)
Pfizer, Cardiovascular & Metabolic Disease Research Unit (2015)
Ludwig Cancer Research Center, Inaugural Symposium, Harvard (2015)
US Oncology Network Clinical Science Meeting, Dallas (2015)
Stanford, University, Chemical & Systems Biology Dept. (2015)
American Association for Cancer Research, Philadelphia (2015)
Metabolism, Diet and Disease: Cancer and Metabolism (2014)
American Association for Cancer Research (2014)
Yale University, Department of Chemistry (2013)
University of Pennsylvania, Dept. of Biochemistry & Biophysics (2013)
Cancer Research UK, Cambridge University (2013)
University of Pennsylvania, ITMAT Symposium (2013)
Harvard Medical School, Dept. of Systems Biology (2013)
Duke University School of Medicine, Depts. of Pharmacology & Cancer
Biology (2013)
Cancer Institute of New Jersey (2013)
Systems Biology of Infection Symposium, Switzerland (2013)
MIT, Koch Institute for Integrative Cancer Research (2013)
American Society for Microbiology (2013)
American Society for Biochemistry and Molecular Biology Conference (2013)
Keystone Symposium on Tumor Metabolism (2013)
University of Chicago (2012)
United Mitochondrial Disease Foundation (2012)
Memorial Sloan-Kettering Cancer Center (2012)
American Association for Cancer Research, Annual Meeting (2012)
New York Academy of Science (2012)
AFOSR Bioenergy Program Review (2011)
CONO 2011 / Viral Ed Conference (2011)
Rockefeller University (2011)
SU2C Team Meeting (2011)
PhytoMetaSyn Project, Annual Meeting (2011)
Broad Institute (2011)
NJ Governor’s Conference on Effective Partnering in Cancer Research (2011)
Case Western University (2011)
International Conference on Systems Biology, Edinburgh (2010)
Metabolomics Society, Amsterdam (2010)
IEEE International Conference on Bioinformatics & Bioengineering (2010)
American Association for Cancer Research, Washington, DC (Speaker & Session Chair) (2010)
New York Academia of Sciences, Hot Topic Symposium, Learning from the Metabolome (2010)
Department of Energy, Genomic Sciences Meeting (Plenary Speaker) (2010)
Cold Spring Harbor Laboratory (2009)
National Institutes of Health, Cancer Cell Metabolism Workshop (2009)
Dana Farber Cancer Institute, Kidney Cancer Program
(Keynote Speaker) (2009)
University of Pennsylvania, Institute for Diabetes,
Obesity & Metabolism (2009)
University of Tennessee, Department of Chemistry (2009)
Vanderbilt University, Institute of Chemical Biology (2009)
Stanford University, Department of Bioengineering (2008)
University of California-Berkeley, Department of Microbiology (2008)
Harvard University, Medical School, Department of Cell Biology (2008)
University of California-San Diego, Department of Bioengineering (2008)
Institute for Advanced Study, Department of Systems Biology (2008)
University of Pennsylvania, Medical School, Cancer and Diabetes Metabolism
Seminar (2008)
Scripps Research Institute, Center for Mass Spectrometry (2008)
Harvard University, FAS Center for Systems Biology (2008)
INVENTORSHIP
Inventor of 160 patents issued by U.S. Patent and Trademark Office
Inventor of five drug products in FDA-sanctioned clinical testing.
- The most advanced product treats acute agitation in bipolar and
schizophrenic patients. It has successfully completed two phase 3
clinical trials and will be submitted for FDA approval shortly.
- The other products (several of which are in Phase II trials) treat migraine
headache, panic attacks, insomnia, and cancer pain.
ACTIVE GRANTS
Principal Investigator, NIH Pioneer, 09/2016-07/2021
Metabolism in Action: Quantitative Fluxes in Mammals
Principal Investigator, SU2C, 12/2015-11/2018
Reprogramming of Transcriptional Circuitry to Control Pancreatic Cancer
Co-Investigator, NIH, 07/2014-06/2018
The Regulation of Cell Metabolism and Proliferation by mTOR Complex 2
Principal Investigator, NIH, 08/2012–06/2022
Identification of Metabolic Vulnerabilities of Ras-Driven Cancer Cells
Principal Investigator, DOE, 09/2014–08/2017
Quantitative Analysis of Metabolic Regulation by Integration of Metabolomics, Proteomics, and Fluxomics
Principal Investigator, Pfizer, 12/2016-05/2020
Targeting Identification/Validation through Quantifying NADPH Flux & Mapping Consumption into de novo lipogenesis (DNL) in Models of NASH/NAFLD
TEACHING
Undergraduate: A Quantitative, Integrative Introduction to the Sciences,
Parts V and VI (with D. Botstein and E. Wieschaus)
A uniquely mathematics-intensive introduction to genetics, physiology, and organic and biological chemistry for college sophomores
Graduate: Biophysical Chemistry I and II
A quantitatively rigorous treatment of biological chemistry for first year science graduate students
Chemical Biology II
A chemically and quantitatively rigorous treatment of metabolism and protein synthesis with a focus on modern advances and techniques
Organic Chemistry of Metabolism
An alternative to the traditional 2-semester sequence in organic chemistry, which teaches the most biologically important reactions through examples drawn from metabolism