Publications

 

190. Davila, A., Liu, L., Chellappa, K., Redpath, P., Nakamaru-Ogiso, E., Paolella, L. M., Zhang, Z., Migaud, M. E., Rabinowitz, J. D., Baur, J. A. (2018) Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife, 2018 June 12, 7.pii: e33246. [Epub ahead of print]

189. Nofal, M. and Rabinowitz, J. D. (2018) Ribosomes on the night shift. Science, 360(6390): 710-711.

188. Jang, C., Chen, L., Rabinowitz, J. D. (2018) Metabolomics and isotope tracing. Cell, 173(4): 822-837.

187. Liu, L., Su, X., Quinn, W. J. 3rd, Hui, S., Krukenberg, K., Frederick,D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., Migaud, M., Mitchison, T. J., Baur, J. A., Rabinowitz, J. D. (2018) Quantitative analysis of NAD synthesis-breakdown fluxes. Cell Metab., 27(5): 1067-1080 e5.

186. Miller, R. A., Shi, Y., Lu, W., Pirman, D. A., Jatkar, A., Blatnik, M., Wu, H., Cárdenas, C., Wan, M., Foskett, J. K., Park, J. O., Zhang, Y., Holland, W. L., Rabinowitz, J. D., Birnbaum, M. J. (2018) Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat. Med., 24(4): 518-524.

185. Lanaspa, M. A., Andres-Hernando, A., Orlicky, D. J., Cicerchi, C., Jang, C., Li, N., Milagres, T., Kuwabara, M., Wempe, M. F., Rabinowitz, J. D., Johnson, R. J., Tolan, D. R. (2018) Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sesitive mice. J. Clin. Invest., 128(6): 2226-2238.

184. Gibney, P. A., Schieler, A., Chen, J. C., Bacha-Hummel, J. M., Botstein, M., Volpe, M. Silverman, S. J., Xu, Y., Bennett, B. D., Rabinowitz, J. D., Botstein, D. (2018) Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Mol. Biol. Cell, 29(8): 897-910.

183. McKee, S. E., Zhang, S., Chen, L., Rabinowitz, J. D., Reyes, T. (2018) Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain. J. Neurochem., 145(5): 362-373.

182. Jang, C. J., Hui, S., Lu, W., Cowan, A. J., Morscher, R. J., Lee, G., Liu, W., Tesz, G. J., Birnbaum, M. J., Rabinowitz, J. D. (2018) The small intestine converts dietary fructose into glucose and organic acids. Cell Metab., 27: 351-361.

181. Morscher, R. J., Ducker, G. S., Li, S. H., Mayer, J. A., Gitai, Z., Sperl, W., Rabinowitz, J. D. (2018) Mitochondrial translation requires folate-dependent tRNA methylationNature, 554: 128-132.

180. Pavlova, N. N., Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., Zhang, J. (2018) As extracellular glutamine levels decline, asparagine becomes an essential amino acidCell Metab., 27(2): 428-438.e5.

179. Lin, K. C., Torga, G., Wu, A., Rabinowitz, J. D., Murray, W. J., Sturm, J. C., Pienta, K. J., Austin R. (2017) Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape. Converg. Sci. Phys. Oncol., 3(4): pii: 045001.

178. Lee, G., Zheng, Y., Cho, S., Jang, C.,England, C., Dempsey, J. M., Yu, Y., Liu, X., He, L., Cavaliere, P. M., Chavez, A., Zhang, E., Isik, M., Couvillon, A., Dephoure, N. E., Blackwell, T. K., Yu, J. J., Rabinowitz, J. D., Cantley, L. C., Blenis, J. (2017) Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signalingCell, 171(7): 1545-1558.

177. Ducker, G. S., Ghergurovich, J. M., Mainolfi, N., Suri, V., Jeong, S. K., Hsin-Jung, Li S., Friedman, A., Manfredi, M. G., Gitai, Z., Kim, H., Rabinowitz, J. D. (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphomaProc. Natl. Acad. Sci. USA, 114(43): 11404-11409.

176. Hui, S., Ghergurovich, J. M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Le, Z., Yanxiang Guo, J., White, E., Rabinowitz, J. D. (2017) Glucose feeds the TCA cycle via circulating lactateNature, 551(7678): 115-118.

175. Wooldridge, A. L., Bischof, R. J., Liu, H., Heinemann, G. K., Hunter, D. S., Giles, L. C., Simmons, R. A., Lien, Y. C., Rabinowitz, J. D., Kind, K. L., Owens, J. A., Clifton, V. L., Gatford, J. L. (2017) Late gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGRAm. J. Physiol. Regul. Integr. Comp. Physiol, 314(1): R22-R33.

174.Liu, L. X., Rowe, G. C., Yang, S., Li. J., Damilano, F., Chan, M. C., Lu, W., Jang, C., Wada, S., Morley, M., Hesse, M., Fleischmann, B. K., Rabinowitz, J., Das, S., Rosenzweig, A., Arany, Z. (2017) PDK4 inhibits cardiac pyruvate oxidation in late pregnancy. Cir. Res., 121(12): 1370-1378.

173. Kim, H. I., Raffler, J., Lu, W., Lee, J. J., Abbey, D., Saleheen, D., Rabinowitz, J. D., Bennett, M. J., Hand, N. J., Brown, C., Rader, D. J. (2017) Fine mapping and functional analysis reveal a role of SLC22A1 in acylcarnitine transportAm. J. Hum. Genet., 101(4): 489-502.

172. Nofal, M., Zhang, K., Han, S., Rabinowitz, J. D. (2017) mTOR inhibition restores amino acid balance in cells dependent on catabolism of extracellular proteinMol. Cell, 67(6): 936-945.e5.

171. Zhang, Z., Chen, L., Liu, L., Su, X., Rabinowitz, J. D. (2017) Chemical basis for deuterium labeling of fat and NADPHJ Am Chem Soc, 139(41): 14368-14371. 

170. Zhang, Y., Kurupati, R., Liu, L., Zhou, X. Y., Zhang, G., Hudaihed, A., Filisio, F., Giles-Davis, W., Xu, X., Karakousis, G. C., Schuchter, L. M., Xu, W., Amaravadi, R., Xiao, M., Sadek, N., Krepler, C., Herlyn, M., Freeman, G. J., Rabinowitz, J. D., Ertl, H. C. J. (2017) Enhancing CD8+ T cell fatty acid catabolism within a metabolically challenging tumor microenvironment increases the efficacy of melanoma immunotherapyCancer Cell, 32(3): 377-391.e9.

169. Chen, L., Ducker, G. S., Lu, W., Teng, X., Rabinowitz, J. D. (2017) An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolateAnal. Bioanal. Chem., 409(25): 5955-5964.

168. Oslund, R. C., Su, X., Haugbro, M., Kee, J. M., Esposito, M., David, Y., Wang, B., Ge, E., Perlman, D. H., Kang, Y., Muir, T. W., Rabinowitz, J. D. (2017) Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerateNat. Chem. Biol., 13(10): 1081-1087.

167. Song, Y., Marmion, R. A., Park, J. O., Biswas, D., Rabinowitz, J. D., Shvartsman, S. Y. (2017) Dynamic control of dNTP synthesis in early embryos. Dev. Cell., 42(3): 301-308.e3,

166. Lu, W., Su, X., Klein, M. S., Lewis, I. A., Fiehn, O., Rabinowitz, J. D. (2017) Metabolite measurement: Pitfalls to avoid and practices to followAnnu. Rev. Biochem., 86: 277-304.

165. Rajeshkumar, N. V., Yabuuchi, S., De Oliveira, E., Kamphorst, J. J., Rabinowitz, J. D., Tejero, H., Al-Shahrour, F., Hidalgo, M., Maitra, A., Dang, C. V. (2017) Treatment of pancreatic cancer patient-derived xenograft panel with metabolic inhibitors reveals efficacy of phenforminClin. Cancer Res., 23(13): 5639-5647.

164. Gong, Y., Cao, R., Ding, G., Hong, S., Zhou, W., Lu, W., Damle, M., Fang, B., Wang, C. C., Qian, J., Lie, N., Lanzillotta, C., Rabinowitz, J. D., Sun, Z. (2017) Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol. Cell Endocrinol., pii: S0303-7207(17)30293-9. [Epub ahead of print]

163. Choi, J., Rajagopal, A. Xu, Y. F., Rabinowitz, J. D., O'Shea, E. K. (2017) A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiaePLoS One, 12(5): e0176085.

162. Lu, W., Wang, L., Chen, L., Hui, S., Rabinowitz, J. D. (2017) Extraction and quantitation of NAD(P)(H)Antioxid. Redox Signal, 2017 July 19 [Epub ahead of print]

161. Su, X., Lu, W., Rabinowitz, J. D. (2017) Metabolite spectral accuracy on orbitrapsAnal. Chem., 89(11): 5940-5948.

160. Davidson, S. M., Jonas, O., Keibler, M. A., Hou, H. W., Luengo, A., Mayers, J. R., Wyckoff, J., Del Rosario, A. M., Whitman, M., Chin, C. R., Condon, K. J., Lammers, A., Kellersberger, K. A., Stall, B. K., Stephanopoulos, G., Bar-Sagi, D., Han, J., Rabinowitz, J. D., Cima, M. J., Langer, R., Vander Heiden, M. G. (2016) Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumorsNat. Med., 23(2): 235-241.

159. Hong S., Zhou, W., Fang, B., Lu, W., Loro, E., Damle M., Ding, G., Jager, G., Zhang, S., Zhang, Y., Feng, D., Chu, Q., Dill, B. D., Molina, H., Khurana, T. S., Rabinowitz, J. D.,Lazar, M. A., Sun, Z. (2016) Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletionNat. Med., 23(2): 223-234.

158. Papazyan, R., Sun, Z., Kim, Y. H., Titchenell,P. M., Hill, D. A., Lu, W., Damle, M., Wan, M., Zhang, Y., Briggs, E. R., Rabinowitz, J. D., Lazar, M. A. (2016) Physiological suppression of lipotoxic liver damage by complementary actions of HDAC3 and SCAP/SREBPCell Metab., 24(6): 863-874.

157. Hackett, S. R., Zanotelli, V. R., Xu, W., Goya, J., Park, J. O., Perlman, D. H., Gibney, P. A., Botstein, D., Storey, J. D., Rabinowitz, J. D. (2016) Systems-level analysis of mechanisms regulating yeast metabolic fluxScience, 354(6311). pii:aaf2786.

156. Ducker, G. S. and Rabinowitz, J. D. (2016) One-carbon metabolism in health and diseaseCell Metab., 25(1): 27-42..

155. Moloughney, J. G., Kim, P. K., Vega-Cotto, N. M., Wu, C. C., Zhang, S., Adlam, M., Lynch, T., Chou, P. C., Rabinowitz, J. D., Werlen, G., Jacinto, E. (2016) mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1Mol. Cell, 63(5): 811-26.

154. Guo, J. Y., Teng, X., Laddha, S. V., Ma, S., Van Nostrand, S. C., Yang, Y., Khor, S., Chan, C. S., Rabinowitz, J. D., White, E. (2016) Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cellsGenes Dev., 30(15): 1704-17.

153. Frederick, D. W., Loro, E., Liu, L., Davila, A. Jr.,Chellappa, K., Silverman, I. M., Quinn, W. J. 3rd, Gosai, S. J., Tichy, E. D., Davis, J. G., Mourkioti, F., Gregory, B. D., Dellinger, R. W., Redpath, P., Migaud, M. E., Nakamaru-Ogiso, E., Rabinowitz, J. D., Khurana, T. S., Baur, J. A. (2016) Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscleCell Metab., 24(2): 269-82.

152. Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., Gygi, S., Rabinowitz, J. D., Sharpe, A. H., Haigis, M. C. (2016) Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activationCell Metab. 24(1): 104-107.

151.Teng, X., Emmett, M. J., Lazar, M. A., Goldberg, E., Rabinowitz, J. D. (2016) Lactate dehydrogenase C produces S-2-Hydroxyglutarate in mouse testisACS Chem. Biol., 11(9): 2420-7.

150. Titchenell, P. M., Quinn, W. J., Lu, M., Chu, Q., Lu, W., Li, C., Chen, H., Monks, B, R., Chen, J., Rabinowitz, J. D., Birnbaum, M. J. (2016) Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose productionCell Metab., 23(6): 1154-66. 

149. Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., Rabinowitz, J. D. (2016) Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathwayCell Metab., 23(6): 1140-53. 

148. Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Shlomi, T., Rabinowitz, J. D. (2016) Metabolite concentrations, fluxes and free energies imply efficient enzyme usageNat. Chem. Biol., 12(7): 482-9.

147. Bren, A., Park, J. O., Towbin, B. D., Dekel, E., Rabinowitz, J. D., Alon, U. (2016) Glucose becomes one of the worst carbon sources for E. coli on poor nitrogen sources due to suboptimal levels of cAMPSci. Rep., 6: 24834.

146. Rabinowitz, J. D., Coller, H. A. (2016) Partners in the Warburg effectElife, 5: e15938.

145. Liu, L., Shah, S., Fan, J., Park, J. O., Wellen, K. E., Rabinowitz, J. D. (2016) Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usageNat. Chem. Biol., 12(5): 345-52.

144. Koivunen, P., Fell, S. M., Lu, W., Rabinowitz, J. D., Kung, A. L., Schlisio, S. (2016) The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor 1α in cancer cells, induces cell death, and reduces tumor xenograft growthHypoxia, 4: 15-27. 

143. Jang, C., Oh, S. F., Wada, S., Rowe, G. C., Liu, L., Chan, M. C., Rhee, J., Hoshino, A., Kim, B., Ibrahim, A., Baca, L. G., Kim, E., Ghosh, C. C., Parikh, S. M., Jiang, A., Chu, Q., Forman, D. E., Lecker, S. H., Krishnaiah, S., Rabinowitz, J. D., Weljie, A. M., Baur, J. A., Kasper, D. L., Arany, Z. (2016) A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistanceNat. Med., 22(4): 421-6.

142. Zong, W. X., Rabinowitz, J. D., White, E. (2016) Mitochondria and cancerMol. Cell, 61(5): 667-76.

141. Su, X., Wellen, K. E., Rabinowitz, J. D. (2016) Metabolic control of methylation and acetylationCurr. Opin. Chem. Biol., 30: 52-60.

140. Bott, A. J., Peng, I. C., Fan, Y., Faubert, B., Zhao, L., Li, J., Neidler, S., Sun, Y., Jaber, N., Krokowski, D., Lu, W., Pan, J. A., Powers, S., Rabinowitz, J., Hatzoglou, M., Murphy, D. J., Jones, R., Wu, S., Girnun, G., Zong, W. X. (2015) Oncogenic Myc induces expression of glutamine synthetase through promoter demethylationCell Metab., 22(6): 1068-77.

139. Mok, W. W., Park, J. O., Rabinowitz, J. D., Brynildsen, M. P. (2015) RNA futile cycling in model persisters derived from MazF accumulationMBio, 6(6). pii: e01588-15.

138. Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., de Wilde, R. F., Matrinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., Dang, C. V., Gillies, R. J., Maitra, A. (2015) Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 functionCancer Res., 75(16): 3355-64.

137. Gibney, P. A., Schieler, A., Chen, J. C., Rabinowitz, J. D., Botstein, D. (2015) Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporterProc. Natl. Acad. Sci. USA, 112(9): 6116-21.

136. Purdy, J. G., Shenk, T., Rabinowitz, J. D. (2015) Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus applicationCell Rep., 10(8): 1375-85. 

135. Buescher, J. M., et. al. (2015) A roadmap for interpreting 13C metabolite labeling patterns from cellsCurr. Opin. Biotechnol., 34C: 189-201.

134. Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka,E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., Thompson, C. B., Rabinowitz, J. D. (2015) Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular proteinCancer Res., 75(3): 544-53.

133. Ducker, G. S. and Rabinowitz, J. D. (2015) ZMP: A master regulator of one-carbon metabolismMol. Cell, 57(2): 203-4.

132. Xu, Y. F., Lu, W., Rabinowitz, J. D. (2015) Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomesAnal. Chem., 87(4): 2273-81.

131. Aristilde, L., Lewis, I. A., Park, J. O., Rabinowitz, J. D. (2014) Hierarchy in pentose sugar metabolism in clostridium acetobutylicumAppl. Environ. Microbiol., 81(4): 1452-62. 

130. Hwang, J., Purdy, J. G., Wu, K., Rabinowitz, J. D., Shenk, T. (2014) Estrogen-related receptor α is required for efficient human cytomegalovirus replicationProc. Natl. Acad. Sci. USA, 111(52): E5706-17.

129. Kamphorst, J. J., Chung, M. K., Fan, J., Rabinowitz, J. D. (2014) Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer & Metabolism, 2: 23.

128. Fan, J., Teng, X., Liu, L., Mattaini, K. R., Looper, R. E., Vander Heiden, M. G., Rabinowitz, J. D. (2014) Human phosphoglycerate dehydrogenase produces the oncometabolite d-2-hydroxyglutarateACS Chem Biol., 10(2): 510-6.

127. Castellana, M., Wilson, M. Z., Xu, Y., Joshi, P., Cristea, I. M., Rabinowitz, J. D., Gitai, Z., Wingreen, W. S. (2014) Enzyme clustering accelerates processing of intermediates through metabolic channelingNat. Biotechnol., 32(10): 1011-8. 

126. Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M., Campbell, K., Cheung, E., Olin-Sandoval, V., Gruening, N. M., Krueger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D., Raiser, M. (2014) The return of metabolism: biochemistry and physiology of the pentose phosphate pathwayBiol. Rev. Camb. Philos. Soc., 2014 Sep 22. Epub ahead of print.

125. Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., Pawel, B., Baggs, J., Cherry, S., Rabinowitz, J. D., Thompson, C. B. (2014) Asparagine plays a critical role in regulating cellular adaptation to glutamine depletionMol. Cell, 56(2): 205-18.

124. Ye, J., Fan, J., Venneti, S., Wan, Y. W., Pawel, B. R., Zhang, J., Finley, L. W., Lu, C., Linsten, T., Cross, J., Qing, G., Liu, Z., Simon, M. C., Rabinowitz, J. D., Thompson, C. (2014) Serine catabolism regulates mitochondrial redox control during hypoxiaCancer Discov., 4(12): 1406-17. 

123. Mathew, R., Khor, S., Hackett, S. R., Rabinowitz, J. D., Perlman, D. H., White, E. (2014) Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunityMol. Cell, 55(6): 916-30.

122. Karsli-Uzunbas, G., Guo, J. Y., Price, S. M., Teng, X., Laddha, S. V., Khor, S., Kalaany, N. Y., Jacks, T., Chan, C. S., Rabinowitz, J. D., White, E. (2014) Autophagy is required for glucose homeostasis and lung tumor maintenanceCancer Discov., 4(8): 914-27. 

121. Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., Rabinowitz, J. D. (2014) Quantitative flux analysis reveals folate-dependent NADPH productionNature, 510(7504): 298-302.

120. Breunig, J. S., Hackett, S. R., Rabinowitz, J. D., Krugkyak, L. (2014) Genetic basis of metabolome variation in yeastPLoS Genet., 10(3): e1004142.

119. Shlomi, T., Fan, J., Tang, B., Kruger, W. D., Rabinowitz, J. D. (2014) Quantitation of cellular metabolic fluxes in methionineAnal. Chem., 86(3): 1583-91.

118. Kliegman, J. I., Fiedler, D., Ryan, C. J., Xu, Y. F., Su, X. Y., Thomas, D., Caccese, M. C., Cheng, A., Shales, M., Rabinowitz, J. D., Krogan, N. J., Shokat, K. M. (2013) Chemical genetics of rapamycin-insensitive TORC2 in s. cerevisiaeCell Rep., 5(6): 1725-36.

117. Fan, J., Kamphorst, J. J., Mathew, R., Chung, M. K., White, E., Shlomi, T., Rabinowitz, J. D. (2013) Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxiaMol. Syst. Biol., 9: 712.

116. Grady, S. L., Purdy, J. G., Rabinowitz, J. D., Shenk, T. (2013) Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infectionProc. Natl. Acad. Sci. USA, 110(51): E5006-15.

115. Tchigvintsev, A., Tchigvintsev, D., Flick, R., Popovic, A., Dong, A., Xu, X., Brown, G., Lu, W., Wu, H., Dombrowski, L., Joo, J. C., Beloglazova, N., Min, J., Savchenko, A., Caudy, A. A., Rabinowitz, J. D., Murin, A. G., Yakunin, A. F. (2013) Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.Chem. Biol., 20(11): 1386-98.

114. Tepper, N., Noor, E., Amador-Noguez, D., Haraldsdóttir, H. S., Milo, R., Rabinowitz, J.,Liebermeister, W., Shlomi, T. (2013) Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite loadPLoS One, 8(9): e75370.

113. Fan, J., Kamphorst, J. J., Rabinowitz, J. D., Shlomi, T. (2013) Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive IDH flux. J. Biol. Chem., 288(43): 31363-9.

112. Rabinowitz, J. D. and Silhavy, T. J. (2013) Systems biology: metabolite turns master regulatorNature, 500(7462): 283-4.

111. Reaves, M.L., Young, B. D., Hosios, A. M., Xu, Y. F., Rabinowitz, J. D. (2013) Pyrimidine homeostasis is accomplished by directed overflow metabolismNature, 500(7461): 237-41.

110. Guo, L. Y., Karsli-Uzunbas, G., Mathew, R., Aisner, S. C., Kamphorst, J.J., Strohecker, A. M., Chen, G., Price, S., Lu, W., Teng, X., Snyder, E., Santanam, U., Dipaola, R. S., Jacks, T., Rabinowitz, J. D., White, E. (2013) Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasisGenes Dev., 27(13): 1447-61.

109. Koyuncu, E., Purdy, J. G., Rabinowitz, J. D., Shenk, T. (2013) Saturated very long fatty acids are required for the production of infectious human cytomegalovirus progenyPLoS Pathog., 9(5): e1003333. 

108. Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., Rabinowitz, J. D. (2013) Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipidsProc. Natl. Acad. Sci. USA, 110(22): 8882-7. 

107. Xu, Y. F., Létisse, F., Absalan, F., Lu, W., Kuznetsova, E., Brown, G., Caudy, A. A., Yakunin, A. F., Broach, J. R., Rabinowitz, J. D. (2013) Nucleotide degradation and ribose salvage in yeastMol. Syst. Biol., 9: 665.

106. Commiso, C., Davidson, S. M., Soydaner-Azeloglu, R. g., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., Rabinowitz, J. D., Metallo, C. M. (2013) Macropinocytosis of protein is an amino acid supply route in Ras-transformed cellsNature, 497(7451): 633-7.

105. Shlomi T. and Rabinowitz, J. D. (2013) Metabolism: Cancer mistunes methylationNat. Chem. Biol., 9(5): 293-4. 

104. Xu, Y. F., Zhao, X., Glass, D. S., Absalan, F., Perlman, D. H., Broach, J. R., Rabinowitz, J. D. (2012) Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylationMol. Cell, 48:52-62. 

103. Bray, K., Mathew, R., Lau, A., Kamphorst, J. J., Fan, J., Chen, J., Chen, H. Y., Ghavami, A., Stein, M., Dipaola, R. S., Zhang, D., Rabinowitz, J. D., White, E. (2012) Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibitionPLoS One, 7(7): e41831. 

102. Reaves, M. L., Sinha, S., Rabinowitz, J. D., Kruglyak, L., Redfield, R. J. (2012) Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cellsScience, 337(6093): 470-3.

101. Grady, S. L., Hwang, J., Vastag, L., Rabinowitz, J. D., Shenk, T. (2012) Herpes simplex virus type 1 infection activates poly (ADP-ribose) polymerase and triggers the degradation of poly (ADP-ribose) glycohydrolaseJ. Virol., 86(15): 8259-68. 

100. Rabinowitz, J. D. and Vastag, L. (2012) Teaching the design principles of metabolism. Nat. Chem.Biol., 8(6):497-501.

99. Xu, Y., Amador-Noguez, D., Reaves, M. L., Feng, X. J., Rabinowitz, J. D. (2012) Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylaseNat. Chem. Biol., 8(6): 562-68.   

98.  Ye, J., Mancuso, A., Tong, X., Ward, P. S., Fan, J., Rabinowitz, J. D., Thompson, C. B. (2012). Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferationProc. Natl. Acad. Sci. USA, 109(18): 6904-09.

97. Peterson, C. N., Levchenko, I., Rabinowitz, J. D., Baker, T. A., Silhavy, T. J. (2012). RpoS proteolysis is controlled directly by ATP levels in Escherichia coliGenes Dev., 26(6): 548-53.

96. Clasquin, M. F, Melamud, E., Rabinowitz, J. D. (2012). LC-MS Data Processing with MAVEN: A Metabolomic Analysis and Visualization EngineCurr. Protoc. Bioinformatics, 14.11.1-14.11.23, March. 

95. Terry, L. J., Vastag, L., Rabinowitz, J. D., Shenk, T. (2012). Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc. Natl. Acad. Sci. USA, 109(8):3071-6. 

94. Rabinowitz, J. D., Purdy, J. G., Vastag, L., Shenk, T., Koyuncu, E. (2011).Metabolomics in drug target discoveryCold Spring Harb. Symp. Quant. Biol., 76: 235-46.

93. Kamphorst, J. J., Fan, J., Lu, W., White, E., Rabinowitz, J. D. (2011). Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolismAnal. Chem., 83(23): 9114-22.  

92. Doucette, C. D., Schwab, D. J., Wingreen, N. S., Rabinowitz, J. D. (2011). α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibitionNat. Chem. Biol., 7(12): 894-901. 

91. Amador-Noguez, D. Brasg, I. A., Feng, X. J., Roquet, N., Rabinowitz, J. D. (2011). Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicumAppl. Environ. Microbiol., 77(22): 7984-97.  

90. Strelko, J. L., Lu, W., Dufort, F. J., Seyfried, T. N., Chiles, T. C., Rabinowitz, J. D., Roberts, M. F. (2011). Itaconic acid is a mammalian metabolite induced during macrophage activationJ. Am. Chem. Soc., 133(41): 16386-9. 

89. Vastag, L., Koyuncu, E., Grady, S. L., Shenk, T. E., Rabinowitz, J. D. (2011). Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolismPLoS Pathog., 7(7): e1002124. 

88.  Liu, S. T. H., Sharon-Frilling, R., Ivanova, P., Milne, S. B., Myers, D. S., Rabinowitz, J. D., Brown, H. A., Shenk, T. (2011). Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egressPNAS, 108(31): 12869-74. 

87. Petti, A. A., Crutchfield, C. A., Rabinowitz, J. D., Botstein, D. (2011). Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial functionProc. Natl. Acad. Sci. USA, 108(45): E1089-98.  

86. Clasquin, M. F., Melamud, E., Singer, A., Gooding, J. R., Xu, X., Dong, A., Cui, H., Campagna, S. R., Savchenko, A., Yakunin, A. F., Rabinowitz, J. D., Caudy, A. A. (2011). Riboneogenesis in yeastCell, 145: 969-980.

85. Reaves, M. L. and Rabinowitz, J. D. (2011). Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvGJ. Bacteriol., 193(18): 4676-81.  

84. Guo, J. X., Chen, H.Y., Mathew, R., Fan, J., Strohecker, A, M., Karsli-Uzunbas, G., Kamphorst, J. J., Chen, G., Lemmons, J. M. S., Karantza, V., Coller, H. A., DiPaola, R. S., Gelinase, C., Rabinowitz, J. D., White, E. (2011). Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesisGenes & Dev., 25460-470. 

83. Klosinska, M. M., Crutchfield, C., Bradley, P. J., Rabinowitz, J. D., Broach, J. R. (2011). Yeast cells can access distinct  quiescent statesGenes Dev., 25(4): 336-49. 

82. Vastag, L., Jorgensen, P., Peshkin, L., Rabinowitz, J. D., Kirschner, M. W. (2011). Remodeling of the metabolome during early frog developmentPLoS ONE, 6(2): e16881.

81. Hart, Y., Madar, D., Yuan, J., Bren, A., Mayo, A. E., Rabinowitz, J. D., Alon, U. (2011) Robust control of nitrogen assimilation by a bifunctional enzyme in E. coliMol. Cell, 41(1): 117-127.

80. Merritt, J. H., Ha, D.G., Cowles, K. N., Lu, W., Morales, D. K., Rabinowitz, J., Gitai, Z., O’Toole, G. A. (2010). Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclasesmBio, 1(4): pii. e00183-10.

79. Wellen, K. E., Lu, Lu, C., Mancuso, A., Lemons, J. M., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., Thompson, C. B. (2010). The hexosamine biosynthetic pathwaycouples growth factor -induced glutamine uptake to glucose metabolismGenes Dev., 24: 2784-2799.  

78. Rabinowitz, J. D. and White, E. (2010). Autophagy and metabolismScience, 330(6009): 1344-8.

77. Melamud, E., Vastag, L., Rabinowitz, J. D. (2010) Metabolomic analysis and visualization engine for LC-MS dataAnal. Chem., 82: 9818-9826.

76. Seltzer, M. J., Bennett, B. D., Joshi, A. D., Gao, P., Thomas, A. G., Ferraris, D. V., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Rabinowitz, J. D., Dang, C. V., Riggins, G. L. (2010). Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1Cancer Res., 70(22): 8981-7. 

75. Reaves, M. L. and Rabinowitz, J. D. (2010) Metabolomics in systems microbiologyCurr. Opin. Biotechnol., 22(1): 17-25. 

74. Lemons, J. M. S., Feng, X. J., Bennett, B. D., Legesse-Miller, A., Johnson, E. L., Raitman, I., Pollina, E. A., Rabitz, H. A., Rabinowitz, J. D., Coller, H. A. (2010). Quiescent fibroblasts exhibit high metabolic activityPLoS Biol., 8 (10): e1000514.

73. Vander Heiden, M. G., Locasale, J. W., Swanson, K.D., Sharfi, H., Heffron, G.J., Amador-Noguez, D., Christofk, H. R., Wagner, G., Rabinowitz, J.D., Asara, J.M., Cantley, L.C. (2010) Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating CellsScience, 329(5998): 1492-1499.

72. Amador-Noguez, D., Feng, X. F., Fan, J.,Roquet, N., Rabitz, H., Rabinowitz, J. D. (2010) Systems-level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicumJ. Bacteriol., 192(17): 4452-4461.

71. Kwon., Y. K., Higgins, M. B., Rabinowitz, J. D. (2010) Antifolate-induced Depletion of Intracellular Glycine and Purines Inhibits Thymineless Death in E. coliACS Chem. Biol., 5: 787-795.

70. Goyal, S., Yuan, J., Chen, T., Rabinowitz, J. D., Wingreen, N. S. (2010) Achieving Optimal Growth through Product Feedback Inhibition in MetabolismPLoS Comput. Biol., 6:e1000802.

69. Goodarzi, H., Bennett, B. D., Amini, S., Reaves, M. L., Hottes, A. K., Rabinowitz, J. D., Tavazoie, S. (2010) Regulatory and Metabolic Rewiring during Laboratory Evolution of Ethanol Tolerance in E. coliMol. Syst. Biol., 6: 378.

68. Crutchfield, C., Lu, W., Melamud, E., Rabinowitz, J. D. (2010)  Mass Spectrometry-Based Metabolomics of YeastMethods Enzymol. 470: 393-426. 

67. Kuchma, S. L., Ballok, A. E., Merritt, J. H., Hammond, J. H., Lu, W., Rabinowitz, J. D., O'Toole, G. A. (2010). Cyclic-di-GMP-Mediated Repression of Swarming Motility by Pseudomonas aeruginosa: The pilY1 Gene and its Impact on Surface-Associated BehaviorsJ. Bacteriol., 192: 2950-64.

66. Lu, W., Clasquin, M. F., Melamud, E., Amador-Noguez, D., Caudy, A. A., Rabinowitz, J. D. (2010) Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometerAnal. Chem., 82: 3212-3221.

65. Monds, R. D., Newell,, P. D., Wagner, J. C., Schwartzman, J. A., Lu, W., Rabinowitz, J. D., O'Toole, G. A. (2010). Di-adenosine tetraphosphate (Ap4A) metabolism impacts biofilm formation by Pseudomonas fluorescens via modulation of c-di-GMP-dependent pathwaysJ. Bacteriol., 192: 3011-23.

64. Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab, O., Bennett, B. D., Coller, H. A., Cross, J. R., Fantin, V. R., Hedvat, C. V., Perl, A. E., Rabinowitz, J. D., Carroll, M., Su, S. M., Sharp, K. A., Levine, T. L., Thompson, C. B. (2010). The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarateCancer Cell, 17: 215-6. 

63. Lu., X., Bennett, B., Mu, E., Rabinowitz, J., Kang, Y. (2010). Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor modelJ. Biol. Chem., 285: 9319-21.

62. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., Rabitz, H. A. (2010). A network flow model for biclustering via optimal re-ordering of data matrices. J. Glob. Optim., 47: 343-354. 

61. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Li, G., Rabinowitz, J. D., Rabitz, H. A. (2010). Enhancing molecular discovery using descriptor-free rearrangement clustering techniques for sparse data setsAIChE Journal, 56: 405-418.

60. Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. (2010). Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitationsMol. Biol. Cell, 21: 198-211.

59. Dang, L., White, D.W., Gross, S., Bennett, B.D., Bittinger, M.A., Driggers, E.M., Fantin, V.R., Jang, H.G., Jin, S., Keenan, M.C., Marks, M., Prins, R.M., Ward, P.S., Yen, K.E., Liau, L.M., Rabinowitz, J.D., Cantley, L.C., Thompson, C.B., Vander Heiden, M.G., Su, S.M. (2009). Cancer-associated IDH1 mutations produce 2-hydroxyglutarateNature, 462: 739-44.

58.  Kelly, R. C., Bolitho, M. E., Higgins, D. A., Lu, W., Ng, W. L., Jeffrey, P. D., Rabinowitz, J. D., Semmelhack, M. F., Hughson, F. M., Bassler, B. L. (2009) The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsANat. Chem. Biol., 5: 891-5. 

57. Yuan, J., Doucette, C., Fowler, W. U., Feng, X. J., Piazza, M., Rabitz, H. A., Wingreen, N. S., Rabinowitz, J. D. (2009). Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Mol. Syst. Biol., 5:302.

56. Bennett, B. D., Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., Rabinowitz, J. D. (2009). Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coliNat. Chem. Biol., 5: 593-9.

55. Olszewski, K. L., Morrisey, J. M., Wilinski, D., Burns, J. M., Vaidya, A. B., Rabinowitz, J. D., Llinás, M. (2009). Host parasite interactions revealed by Plasmodium falciparum metabolomics. Cell Host Microbe, 5:191-9.

54. Shinar, G., Rabinowitz, J. D., Alon, U. (2009). Robustness in glyoxylate bypass regulation. PLoS Comp. Biol., 5: e1000297.

53. Bradley, P. H., Brauer, M. J., Rabinowitz, J. D., Troyanskaya, O. (2009). Coordinated concentration changes of transcript and metabolites in Saccharomyces cerevisiae. PLoS Comp. Biol., 5: e1000270.

52. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., Rabitz, H. A. (2008). Biclustering via optimal re-ordering of data matrices in systems biology: Novel rigorous methods and comparative studies. BMC Bioinformatics, 9: 458.

51. McAllister, S. R., Feng, X. J., Dimaggio, P. A. Jr., Floudas, C. A., Rabinowitz, J. D., Rabitz, H. (2008). Descriptor-free molecular discovery in large libraries by adaptive substituent reorderingBioorg. Med. Chem. Lett., 18: 5967-5970.

50. Munger, J., Bennett, B. D., Parikh, A., Feng, X. J., McArdle, J., Rabitz, H. A., Shenk, T., Rabinowitz, J. D. (2008). Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for anti-viral therapy.Nat. Biotechnol., 26: 1179-1186.

49. Kwon, Y. K., Lu, W., Melamud, E., Khanam, N., Bognar, A., Rabinowitz, J. D. (2008). A domino effect in antifolate drug action in Escherichia coli.Nat. Chem. Biol., 4: 602-608.

48. Yuan, J., Bennett, B. D., Rabinowitz, J. D. (2008).Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nat. Protocols, 3: 1328-1340.

47. Bennett, B. D., Yuan, J., Kimball, E. H., Rabinowitz, J. D. (2008). Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach. Nat. Protocols, 3: 1299-1311.

46. Lu, W., Bennett, B. D., Rabinowitz, J. D. (2008). Analytical strategies for LC-MS-based targeted metabolomics. J. Chrom. B., 871: 236-242.

45. Waters, C. M., Lu, W., Rabinowitz, J. D., Bassler, B. L. (2008). Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J. Bacteriol., 190: 2527-2536.  

44. Rabinowitz, J. D., Hsiao, J. J., Gryncel, K. R., Kantrowitz, E. R., Feng, X. J., Li, G., Rabitz, H. (2008). Dissecting enzyme regulation by multiple allosteric effectors: Nucleotide regulation of aspartate transcarbamoylase.Biochemistry, 47: 5881-5888.

43. Piazza, M., Feng, X. J., Rabinowitz, J. D., Rabitz, H. (2008). Diverse metabolic model parameters generate similar methionine cycle dynamics. J. Theor. Biol., 251: 628-639.

42. Cui, H., Hayashi, A., Sun, H. S., Belmares, M. P., Cobey, C., Phan, T., Schweizer, J., Salter, M. W., Wang, Y. T., Tasker, R. A., Garman, D., Rabinowitz, J., Lu, P. S., Tymianski, M. (2007). PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J. Neurosci., 27: 9901-9915.

41. Xavier, K. B., Miller, S. T., Lu, W., Kim, J. H., Rabinowitz, J., Pelczer, I., Semmelhack, M. F., Bassler, B. L. (2007). Phosphorylation and processing of the quorum-sensing molecule AI-2 in enteric bacteria. ACS Chem. Biol., 2: 128-136.

40. Yuan, J., Rabinowitz, J. D. (2007). Differentiating metabolites formed from de novo synthesis versus macromolecule decomposition. J. Am. Chem. Soc., 129: 9294-9295.  PMCID: PMC2547081

39. Rabinowitz, J. D., Kimball, E. (2007). Acidic acetonitrile for cellular metabolome extraction from Escherichia coli. Anal. Chem., 79: 6167-6173.

38. Lu, W., Kwon, Y. K., Rabinowitz, J.D. (2007).  Isotope ratio-based profiling of microbial folates. J. Am. Soc. Mass Spectr., 18: 898-909.  

37. Campagna, S. R., Rabinowitz, J. D. (2007). Metabolome quantitation mass spectrometry. G.I.T. Laboratory Journal, 7-8: 26-27.

36. Rabinowitz, J. D. (2007). Cellular metabolomics of Escherichia coli.Exp. Rev. Proteomics, 4: 187-198.

35. Avram, M. J., Henthorn, T. K., Spyker, D. A., Krejcie, T. C., Lloyd, P. M., Cassella, J. V., Rabinowitz, J. D. (2007). Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs.Drug. Metab. Dispos., 35: 262-267.

34. Bao, Q., Lu, W., Rabinowitz, J. D., Shi, Y. (2007). Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1.Mol. Cell, 25: 181-192.

33. Myers, D. J., Timmons, R. D., Lu, A. T., Hale, R. L., Solas, D. W., Soni, P., Rabinowitz, J. D. (2007). Effect of film thickness on thermal aerosol generation. Pharm. Res., 24:336-342.

32. Brauer, M. J., Yuan, J., Bennett, B. D., Lu, W., Kimball, E., Botstein, D., Rabinowitz, J. D. (2006). Conservation of the metabolomic response to starvation across two divergent microbes. Proc. Natl. Acad. Sci. USA, 103: 19302-19307.  

31. Munger, J., Bajad, S. U., Coller, H. A., Shenk, T., Rabinowitz, J. D. (2006). Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathogens, 2: 1165.

30. Hess, D. C., Lu, W., Rabinowitz, J. D., Botstein, D. (2006). Ammonium toxicity and potassium limitation in yeast.  PLos Biology, 4: 2012-2023. 

29. Kimball, E., Rabinowitz, J. D. (2006). Identifying decomposition products in extracts of cellular metabolites. Anal. Biochem., 358: 273-80.   

28. Yuan, J., Fowler, W. U., Kimball, E., Lu, W., Rabinowitz, J. D. (2006). Kinetic flux profiling of nitrogen assimilation in Escherichia coli. Nat. Chem. Biol., 2: 529-530.

27. Bajad, S. U., Lu, W., Kimball, E. H., Yuan, J., Peterson, C., Rabinowitz, J. D. (2006). Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography – tandem mass spectrometry. J. Chrom. A., 1125: 76-88.

26. Rabinowitz, J. D., Lloyd, P. M., Munzar, P., Myers, D. J., Cross, S., Damani, R., Quintana, R., Spyker, D. A., Soni, P., Cassella, J. V. (2006). Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation.J. Pharm. Sci., 95: 2438-2451.

25. Lu, W., Kimball, E., Rabinowitz, J. D. (2006). A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolites. J. Am. Soc. Mass Spectr., 17: 37-50.

24. Rabinowitz, J. D., Wensley, M., Lloyd, P., Myers, D., Shen, W., Lu, A., Hodges, C., Hale, R., Mufson, D., Zaffaroni, A. (2004). Fast onset medications through thermally generated aerosols. J. Pharmacol. Exp. Ther., 309: 769-775.

23. Turner-Cobb J. M., Koopman, C., Rabinowitz, J. D., Terr, A. I., Sephton, S. E., Spiegel, D. (2004). The interaction of social network size and stressful life events predict delayed-type hypersensitivity among women with metastatic breast cancer. Int. J. Psychophysiol., 54: 241-249.

22. Hall, F. C., Rabinowitz, J. D., Busch, R., Visconti, K. C., Belmares, M., Patil, N. S., Cope, A. P., Patel, S., McConnell, H. M., Mellins, E. D., Sonderstrup, G. (2002). Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes. Eur. J. Immunol., 32: 662-670.

21. Patil, N. S., Pashine, A., Belmares, M. P., Liu, W., Kaneshiro, B., Rabinowitz, J., McConnell, H., Mellins, E. D. (2001). Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles.J. Immunol., 167: 7157-7168.

20. Belmares, M. P., Rabinowitz, J. D., Lui, W., Mellins, E. D., McConnell, H. M. (2000). pH stability of HLA-DR4 complexes with antigenic peptides. Biochemistry, 39: 14558-14566.

19. Kasson, P. M., Rabinowitz, J. D., Schmitt, L., Davis, M. M., McConnell, H. M. (2000). Kinetics of peptide binding to the class II MHC protein I-Ek.Biochemistry, 39: 1048-1058.

18. Rabinowitz, J. D., Vrljic, M., Kasson, P. M., Liang, M. N., Busch, R., Boniface, J. J., Davis, M. M., McConnell, H. M. (1998). Formation of a highly peptide-receptive state of class II MHC. Immunity, 9: 699-709.

17. Boniface, J. J., Rabinowitz, J. D., Wulfing, C., Hampl, J., Reich, Z., Altman, J. D., Kantor, R. M., Beeson, C., McConnell, H. M., Davis, M. M. (1998). Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity, 9: 459-466.

16. Lee, C., Liang, M. N., Tate, K. M., Rabinowitz, J. D., Beeson, C., Jones, P. P., McConnell, H. M. (1998). Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft. J. Exp. Med., 187: 1505-1516.

15. Rabinowitz, J. D., Vacchino, J. F., Beeson, C., McConnell, H. M. (1998). Potentiometric measurement of intracellular redox activity. J. Am. Chem. Soc., 120: 2464-2473.

14. Petros, W. P., Rabinowitz, J., Gibbs, J. P., Hall, I. H., Stuart, A. R., Peters, W. P. (1998).Effect of plasma TNF-α on filgrastim-stimulated hematopoiesis in mice and humans.   Pharmacotherapy, 18: 816-823.

13. Rabinowitz, J. D., Liang, M. N., Tate K., Lee C., Beeson C., McConnell H. M. (1997). Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex. Proc. Natl. Acad. Sci. USA, 94: 8702-8707.

12. Rabinowitz, J. D., Rigler P., Carswell-Crumpton, C., Beeson, C., McConnell, H. M. (1997). Screening for novel drug effects with a microphysiometer: a potent effect of clofilium unrelated to potassium channel blockade. Life Sci., 61: PL87-PL94.

11. Elkordy, M., Crump, M., Vredenburgh, J. J., Petros, W. P., Hussein, A., Rubin, P., Ross, M., Gilbert, C., Modlin, C., Meisenberg, B., Coniglio, D., Rabinowitz, J., Laughlin, M., Kurtzberg, J., Peters, W. P. (1997). A phase I trial of recombinant human interleukin-1 beta (OCT-43) following high-dose chemotherapy and autologous bone marrow transplantation. Bone Marrow Transpl., 19: 315-322.

10. Petros, W. P., Rabinowitz, J., Stuart, A., Peters W. P. (1997). Clinical pharmacology of filgrastim following high-dose chemotherapy and autologous bone marrow transplantation. Clin. Cancer Res., 3: 705-711.

9. Wulfing, C., Rabinowitz, J. D., Beeson C., Sjaastad M. D., McConnell H. M., Davis M. M. (1997). Kinetics and extent of T cell activation as measured with the calcium signal. J. Exp. Med., 185: 1815-1825.

8. Rabinowitz, J. D., Beeson, C., Wulfing C., Tate K., Allen P. M., Davis M. M., McConnell, H. M. (1996). Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity, 5: 125-135.

7. Rabinowitz, J. D., Beeson C., Lyons D. S., Davis M. M., McConnell, H. M. (1996). Kinetic discrimination in T-cell activation. Proc. Natl. Acad. Sci. USA, 93: 1401-1405.

6. Beeson, C., Rabinowitz, J., Tate, K., Gutgemann, I., Chien, Y. H., Jones, P. P., Davis, M. M., McConnell, H. M. (1996). Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface. J. Exp. Med., 184: 777-782.

5. Petros, W. P., Rosner, G. L., Rabinowitz, J., Gilbert, C. J., Coniglio, D., Vredenburgh J. J., Ross, M., Peters, W. P. (1996). The pharmacologic effects of recombinant, human colony-stimulating factors and their modulation by theophylline. Pharmacotherapy, 16: 742-748.

4. Petros W. P., Rabinowitz, J., Stuart A. R., Gupton C., Alderman, E. M., Peters, W. P. (1994). Elevated endogenous serum macrophage colony-stimulating factor in the early stage of fungemia following bone marrow transplantation. Exp. Hematol., 22: 582-586.

3. Rabinowitz, J., Petros, W. P., Peters, W. P. (1994). Cytokine kinetics: Clinical pharmacology studies complementing recombinant growth factor trials. Cancer Bulletin, 46: 40-47.

2. Rabinowitz, J., Petros, W. P., Stuart, A. R., Peters, W. P. (1993). Characterization of endogenous cytokine concentrations after high-dose chemotherapy with autologous bone marrow support. Blood, 81: 2452-2459.

1. Petros W. P., Rabinowitz, J., Stuart, A. R., Gilbert, C. J., Kanakura, Y., Griffin, J. D., Peters, W. P. (1992). Disposition of recombinant human granulocyte-macrophage colony-stimulating factor in patients receiving high-dose chemotherapy and autologous bone marrow support. Blood, 80: 1135-1140.