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277. Jankowski, C. S. R., Rabinowitz, J. D. (2022) Selenium modulates cancer cell response to pharmacologic ascorbate. Cancer Res., 82: 3486-3498.

276. Jang, C., Hui, S., Zeng, X., Cowan, A. J., Wang, L., Chen, L., Morscher, R. J., Reyes, J., Frezza, C., Hwang, H. Y., Imai, A., Saito, Y., Okamoto, K., Vaspoli, C., Kasprenski, L., Zsido, G. A. 2nd, Gorman, J. H. 3rd, Gorman, R. C., Rabinowitz, J. D. (2022) Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metab., 34:1410.

275. Zeng, X., Xing, X., Gupta, M., Keber, F. C., Lopez, J. G., Lee, Y. J., Roichman, A., Wang, L., Neinast, M. D., Donia, M. S., Wühr, M., Jang, C., Rabinowitz, J. D. (2022) Gut bacterial nutrient preferences quantified in vivo. Cell, 185: 3441-3456.e19.

274. Xiao, T., Khan, A., Shen, Y., Chen, L., Rabinowitz, J. D. (2022) Glucose feeds the tricarboxylic acid cycle via excreted ethanol in fermenting yeast. Nat Chem Biol., Aug 15. doi: 10.1038/s41589-022-01091-7.

273. Zhang, Y., Xu, Y., Lu, W., Li, J., Yu, S., Brown, E. J., Stanger, B. Z., Rabinowitz, J. D., Yang, X. (2022) G6PD-mediated increase in de novo NADP+ biosynthesis promotes antioxidant defense and tumor metastasis. Sci Adv, 8: eabo0404.

272. Lindell, R. B., Zhang, D., Bush, J., Wallace, D. C., Rabinowitz, J. D., Lu, W., Wherry, E. J., Weiss, S. L., Henrickson, S. E.(2022) Impaired Lymphocyte Responses in Pediatric Sepsis Vary by Pathogen Type and Are Associated with Features of Immunometabolic Dysregulation. Shock, 57: 191-199.

271. Olszewski, K., Barsotti, A., Feng, X. J., Momcilovic, M., Liu, K.G., Kim, J. I., Morris, K., Lamarque, C., Gaffney, J., Yu, X., Patel, J. P., Rabinowitz, J. D., Shackelford, D. B., Poyurovsky, M. V. (2022)  Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol., 29: 423-435.e.10.

270. Nofal, M., Wang, T., Yang, L., Jankowski, C. S. R., Hsin-Jung, L. S., Han, S., Parsons, L., Frese, A. N., Gitai, Z., Anthony, T. G., Wühr, M., Sabatini, D. M., Rabinowitz, J. D. (2022) GCN2 adapts protein synthesis to scavenging-dependent growth. Cell Syst., 13: 158-172.

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268. Wang, L., Xing, X., Zeng, X., Jackson, S. R., TeSlaa, T., Al-Dalahmah, O., Samarah, L. Z., Goodwin, K., Yang, L., McReynolds, M. R., Li, X., Wolff, J. J., Rabinowitz, J. D., Davidson, S. M. (2022) Spatially resolved isotope tracing reveals tissue metabolic activity. Nat Methods, 19: 223-230.

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262. Ghergurovich, J. M., Xu, X., Wang, J. Z., Yang, L., Ryseck, R. P., Wang, L., Rabinowitz, J. D. (2021) Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab., 3: 1512-1520.

261. Ding H, Chen Z, Wu K, Huang SM, Wu WL, LeBoeuf SE, Pillai RG, Rabinowitz JD, Papagiannakopoulos T. (2021) Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition. Sci Adv., 7: eabk1023.

260. Chen, L., Lu, W., Wang, L., Xing, X., Chen, Z., Teng, X., Zeng, X., Muscarella, A. D., Shen, Y., Cowan, A., McReynolds, M. R., Kennedy, B. J., Lato, A. M., Campagna, S. R., Singh, M., Rabinowitz, J. D. (2021) Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods, 18:1377-1385.

259. Parkhitko, A. A., Wang, L., Filine, E., Jouandin, P., Leshchiner, D., Binari, R., Asara, J. M., Rabinowitz, J. D., Perrimon, N. (2021)  A genetic model of methionine restriction extends Drosophila health- and lifespan. Proc Natl Acad Sci U S A, 118(40):e2110387118.

258. Garcia-Canaveras, J. C., Heo, D., Trefely, S., Leferovich, J., Xu, C., Philipson, B. I., Ghassemi, S., Milone, M. C., Moon, E. K., Snyder, N. W., June, C. H., Rabinowitz, J. D., O'Connor, R. S. (2021) CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production. Cells., 10: 2334.

257. McReynolds, M. R., Chellappa, K., Chiles, E., Jankowski, C., Shen, Y., Chen, L., Descamps, H. C., Mukherjee, S., Bhat, Y. R., Lingala, S. R., Chu, Q., Botolin, P., Hayat, F., Doke, T., Susztak, K., Thaiss, C. A., Lu, W., Migaud, M. E., Su, X., Rabinowitz, J. D., Baur, J. A. (2021) NAD+ flux is maintained in aged mice despite lower tissue concentrations. Cell Syst., 12: 1160-1172.

256. Cable, J., Pourquié, O., Wellen, K. E., Finley, L. W. S., Aulehla, A., Gould, A. P., Teleman, A., Tu, W. B., Garrett, W. S., Miguel-Aliaga, I., Perrimon, N., Hooper, L. V., Walhout, A. J. M., Wei, W., Alexandrov, T., Erez, A., Ralser, M., Rabinowitz, J. D., Hemalatha, A., Gutiérrez-Pérez, P., Chandel, N. S., Rutter, J., Locasale, J. W., Landoni, J. C., Christofk, H. (2021) Metabolic decisions in development and disease-a Keystone Symposia report. Ann N Y Acad Sci, 1506: 55-73.

255. Phan, T., Nguyen, V. H., Buettner, R., Morales, C., Yang, L., Wong, P., Tsai, W., d'Alincourt Salazar, M., Gil, Z., Diamond, D. J., Rabinowitz, J. D., Rosen, S., Melstrom, L. G. (2021) Inhibition of de novo pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer. Int. J. Biol. Sci., 17: 2240-2251.

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253. Ghergurovich, J. M., Lang, J. D., Levin, M. K., Briones, N., Facista, S. J., Mueller, E. S. C., Cowan, A. J., McBride, M. J., San Roman Rodriguez, E., Killian, A., Dao, T., Lamont, J., Barron, A., Su, X., Hendricks, W. P. D., Espina, V., Von Hoff, D. D. O'Shaughnessy, J., Rabinowitz, J. D. (2021) Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer. Med (NY), 2: 736-754.

252. Schild, T., McReynolds, M. R., Shea, C., Low, V., Schaffer, B. E., Asara, J. M., Piskounova, E., Dephoure, N., Rabinowitz, J. D., Gomes, A. P., Blenis, J. (2021) NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Rep, 35: 109238.

251. Li, S. H-J., Nofal, M., Parsons, L. R., Rabinowitz, J. D., Gitai, Z. (2021) Monitoring mammalian mitochondrial translation with MitoRiboSeq. Nat Protoc, 16: 2802-2825.

250. Yu, D., Richardson, N. E., Green, C. L., Spicer, A. B., Murphy, M. E., Flores, V., Jang, C., Kasza, I., Nikodemova, M., Wakai, M. H., Tomasiewicz, J. L., Yang, S. E., Miller, B. R., Pak, H. H., Brinkman, J. A., Rojas, J. M., Quinn 3rd, W. J., Cheng, E. P., Konon, E. N., Haider, L. R., Finke, M., Sonsalla, M., Alexander, C. M., Rabinowitz, J. D., Baur, J. A., Malecki, K. C., Lamming, D. W. (2021) The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. Cell Metab, 33: 905-922.e6.

249. Cho, S., Lee, G., Pickering, B. F., Jang, C., Park, J. H., HeL., Mathur, L., Kim, S-S., Jung, S., Tang, H-W., Monette, S., Rabinowitz, J. D., Perrimon, N., Jaffrey, S. R., Blenis, J. (2021) mTORC1 promotes cell growth via m 6 A-dependent mRNA degradation. Mol Cell, 81: 2064-2075.

248. Minhas, P. S., Latif-Hernandez, A., McReynolds, M. R., Durairaj, A. S., Wang, Q., Rubin, A., Joshi, A. U., He, J. Q., Gauba, E., Liu, L., Wang, C., Linde, M., Sugiura, Y., Moon, P. K., Majeti, R., Suematsu, M., Mochly-Rosen, D., Weissman, I. L., Longo, F. M., Rabinowitz, J. D., Andreasson, K. I. (2021) Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature, 590: 122-128.

247. TeSlaa, T., Bartman, C. R., Jankowski, C. S. R., Zhang, Z., Xu, X., Xing, X., Wang, L., Lu, W., Hui, S., Rabinowitz, J. D. (2021) The Source of Glycolytic Intermediates in Mammalian Tissues. Cell Metab, 33: 367-378.e5.

246. García-Cañaveras, J. C., Lancho, O., Ducker, G. S., Ghergurovich, J. M., Xu, X., da Silva-Diz, V., Minuzzo, S., Indraccolo, S., Kim, H., Herranz, D., Rabinowitz, J. D. (2021) SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia, 35:377-388.

245. Parkhitko, A. A., Ramesh, D., Wang, L., Leshchiner, D., Filine, E., Binari, R., Olsen, A. L., Asara, J. M., Cracan, V., Rabinowitz, J. D., Brockmann, A., Perrimon, N. (2020) Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Elife, 9:e58053.

244. Ringel, A. E, Drijvers, J.M., Baker, G. J., Catozzi, A., García-Cañaveras, J. C., Brandon M Gassaway, B. M., Miller, B. C., Juneja, V. R., Nguyen, T. H., Joshi, S., Yao, C-H., Yoon, H., Sage, P. T., LaFleur, M. W., Trombley, J. D., Jacobson, C. A., Maliga, Z., Gygi, S. P., Sorger, P.K., Rabinowitz, J. D., Sharpe, A. H., Haigis, M. C. (2020)  Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity. Cell, S0092-8674(20)31526-9.

243. ChiniC. C. S., et. al. (2020) CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD + and NMN levels. Nat Metab., 2:1284-1304.

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241. Suthers, P. F., Dinh, H. V., Fatma, Z., Shen, Y., Chan, S. H. J., Rabinowitz, J. D., Zhao, H., Maranas, C. D. (2020)  Genome-scale metabolic reconstruction of the non-model yeast Issatchenkia orientalis SD108 and its application to organic acids production. Metab Eng Commun, 11: e00148.

240. Murashige, D., Jang, C., Neinast, M., Edwards, J. J., Cowan, A., Hyman, M. C., Rabinowitz, J. D., Frankel, D. S., Arany, Z. (2020) Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science, 370(6514): 364-368.

239. Luongo, T. S., Eller, J. M., Lu, M-J., Niere, M., Raith, F., Perry, C., Bornstein, M. R., Oliphint, P., Wang, L., McReynolds, M. R., Migaud, M. E.Rabinowitz, J. D.Johnson, F. B.Johnsson K.Ziegler, M.Cambronne, X. A.Baur, J. A. (2020) SLC25A51 is a mammalian mitochondrial NAD + transporter. Nature, 588: 174-179.

238. Green, R., Sonal, Wang, L., Hart, S. F. M., Lu, W., Skelding, D., Burton, J. C., Mi, H., Capel, A., Chen, H. A., Lin, A., Subramaniam, A. R., Rabinowitz, J. D., Shou, W. (2020) Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS Biol., 18: e3000757.

237. Hui, S., Cowan, A. J., Zeng, X., Yang, L., TeSlaa, T., Li, X., Bartman, C., Zhang, Z., Jang, C., Wang, L., Lu, W., Rojas, J., Baur, J., Rabinowitz, J. D. (2020) Quantitative fluxomics of circulating metabolites. Cell Metab., 32: 676-688.e4.

236. Ghassemi, S., Martinez-Becerra, F. J., Master, A. M., Richman, S. A., Heo, D., Leferovich, J.,  Tu, Y., García-Cañaveras, J. C., Ayari, A., Lu, Y., Wang, A., Rabinowitz, J. D., Milone, M. C., June, C. H., O'Connor, R. S. (2020) Enhancing chimeric antigen receptor T cell anti-tumor function through advanced media design. Mol. Ther. Methods Clin. Dev., 18: 595-606.

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234. Guan, D., Xiong, Y., Trinh, T. M., Xiao, Y., Hu, W., Jiang, C., Dierickx, P., Jang, C., Rabinowitz, J. D., Lazar, M. A. (2020) The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science, 369: 1388-1394.

233. Xu, Y., Zhang, Y., García-Cañaveras, J. C., Guo, L., Kan, M., Yu, S., Blair, I. A., Rabinowitz, J. D., Yang, X. (2020) Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science, 369: 397-403.

232. Rabinowitz, J. D., Enerbäck, S. (2020) Lactate: the ugly duckling of energy metabolism. Nature Metab., 2: 566-571.

231. Jang, C., Wada, S., Yang, S., Gosis, B., Zeng, X.,Zhang, Z., Shen, Y., Lee, G., Arany, Z. Rabinowitz, J. D. (2020) The small intestine shields the liver from fructose-induced steatosis. Nat Metab., 2: 586-593.

230. Ghergurovich, J. M., Esposito, M., Chen, Z., Wang, W. Z., Bhatt, V., Lan, T., White, E., Kang, Y., Guo, J. Y., Rabinowitz, J. D. (2020) Glucose-6-phosphate dehydrogenase is not essential for K-Ras-driven tumor growth or metastasis. Cancer Res., 80: 3820-3829.

229. Lu, W., Xing, X., Wang, L., Chen, L., Zhang, S., McReynolds, M. R., Rabinowitz, J. D. (2020) Improved annotation of untargeted metabolomics data through buffer modifications that shift adduct mass and intensity. Anal Chem., 92: 11573-11581.

228. Martin 2nd, J. K., Sheehan, J. P., Bratton, B. P., Moore, G. M., Mateus, A., Li, S. H.-J., Kim, H., Rabinowitz, J. D., Typas,A., Savitski, M. M., Wilson, M. Z., Gitai, Z. (2020) A dual-mechanism antibiotic kills gram-negative bacteria and avoids drug resistance. Cell, 181: 1518-1532.e14.

227. Gibney, P. A.,  Chen, A., Schieler, A., Chen, J. C., Xu, Y., Hendrickson, D. G., McIsaac, R. S., Rabinowitz, J. D., Botstein, D. (2020) A tps1Δ persister-like state in saccharomyces cerevisiae is regulated by MKT1. PLoS One, 15: e0233779.

226. Ghergurovich, J. M., García-Cañaveras, J. C., Wang, J., Schmidt, E., Zhang, Z., TeSlaa, T., Patel, H., Chen, L., Britt, E. C., Piqueras-Nebot, M., Gomez-Cabrera, M. C., Lahoz, A., Fan, J., Beier, U. H., Kim, H., Rabinowitz, J. D. (2020) A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol., 16: 731-739.

225. Zhao, S., Jang, C., Liu, J., Uehara, K., Gilbert, M., Izzo, L., Zeng, X., Trefely, S., Fernandez, S., Carrer, A., Miller, K. D., Zhug, Z. T., Snyder, N. W., Gade, T. P., Titchenell, P. M., Rabinowitz, J. D., Wellen, K. E., (2020) Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature, 579: 586-591.

224. Yang, L., García-Cañaveras, J. C., Chen, Z., Wang, L., Liang, L., Jang, C., Mayr, J. A., Zhang, Z., Ghergurovich, J. M., Zhan, L., Joshi, S., Hu, Z., McReynolds, M. R., Su, X., White, E., Morscher, R. J., Rabinowitz, J. D. (2020) Serine catabolism feeds NADH when respiration is impaired. Cell Metab., 31: 809-821.e6.

223. Hermans, D., Gautam, S., García-Cañaveras, J. C.,Gromer, D., Mitra, S., Spolski, R., Li, P., Christensen, S., Nguyen, R., Lin, J. X., Oh, J., Du, N., Veenbergen, S., Fioravanti, J., Ebina-Shibuya, R., Bleck, C., Neckers, L. M., Rabinowitz, J. D., Gattinoni, L., Leonard, W. J. (2020) Lactate dehydrogenase inhibition synergizeswith IL-21 to promote CD8+ T cell stemness and antitumor immunity. Proc Natl Acad Sci USA, 117: 6047-6055.

222. Li, A. M., Ducker, G. S., Li, Y., Seoane, J. A., Xiao, Y., Melemenidis, S., Zhou, Y., Liu, L., Vanharanta, S., Graves, E. E., Rankin, E. B., Curtis, C., Massagué, J., Rabinowitz, J. D., Thompson, C. B., Ye, J. (2020) Metabolic profiling reveals a dependency of humanmetastatic breast cancer on mitochondrial serine and one-carbon metabolismMol Cancer Res., 18: 599-611.

221. Gokhale, S., Lu, W., Zhu, S., Liu, Y., Hart, R. P., Rabinowitz, J. D., Xie, P. (2019) Elevated choline kinase α-mediated choline metabolism supports the prolonged survival of TRAF3-deficient B lymphocytes. J Immunol., 204: 459-471.

220. Estrella, M. A., Du, J., Chen, L., Rath, S., Prangley, E., Chitrakar, A., Aoki, T., Schedl, P., Rabinowitz, J., Korennykh, A. (2019) The metabolites NADP and NADPH are the targets of the circadian protein nocturnin (curled). Nat Commun., 10: 2367.

219. Dinh, H. V., Suthers, P. F., Chan, S. H. J., Shen, Y., Xiao, T., Deewan, A., Jagtap, S. S., Zhao, H., Rao, C. V., Rabinowitz, J. D., Maranas, C. D. (2019) A comprehensive genome-scale model for Rhodosporidium toruloides IFO0880 accounting for functional genomics and phenotypic data. Metab Eng Commun., 9: e00101.

218. Benson, K. K., Hu, W., Weller, A. H., Chen, E. R., Khetarpal, S. A., Yoshino, S., Bone, W. P., Wang, L., Rabinowitz, J. D., Voight, B. F., Soccio, R. E. (2019) . Natural human genetic variation determines basal and inducible expression of PM20D1, an obesity-associated gene.  Proc Natl Acad Sci USA, 116: 23232-23242.  

217. Park, J. O., Tanner, L. B., Wei, M. H., Khana, D. B., Jacobson, T. B., Zhang, Z., Rubin, S. A., Li, S. H., Higgins, M. B., Stevenson, d. M., Amador-Noguez, D., Rabinowitz, J. D. (2019) Near-equilibrium glycolysis supports metabolic homeostasis and energy yield. Nat Chem Biol,. 15: 1001-1008.

216. Stine, R. R., Sakers, A. P., TeSlaa, T., Kissig, M., Stine, Z. E., Kwon, C. W., Cheng, L., Lim, H. W., Kaestner, K. H., Rabinowitz, J. D., Seale, P. (2019) PRDM16 maintains a homeostasis of the intestinal epithelium by controlling region-specific metabolism. Cell Stem Cell, 25: 830-845.

215. Ron-Harel, N., Ghergurovich, J. M., Notarangelo, G., LaFleur, M. W., Tsubosaka, Y., Sharpe, A., H., Rabinowitz, J. D., Haigis. M. C. (2019) T cell activation depends on extracellular alanine. Cell Rep., 28: 3011-3021.e4.

214. Bailis, W., Shyer, J. A., Zhao, J., García-Cañaveras, J. C., Al Khazal, F. J., Qu, R., Steach, H. R., Bielecki, P., Khan, O., Jackson, R., Kluger, Y., Maher. L. J. 3rd, Rabinowitz, J., Craft, J., Flavell, R. A. (2019) Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function. Nature, 571: 403-407.

213. Dekhne, A. S., Shah, K., Ducker, G. S., Katinas, J. M., Wong-Roushar, J., Nayeen, M. J., Doshi, A., Ning, C., Bao, X., Frühauf, J., Liu, J., Wallace-Povirk, A., O'Connor, C., Dzinic, S. H., White, K., Kushner, J., Kim, S., Hüttermann, M., Polin, L., Rabinowitz, J. D., Li, J., Hou, Z., Dann, C. E., Gangjee, A., Matherly, L. H. (2019) Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy. Mol Cancer Ther., 18: 1787-1799.

212. Liu, Q., Johnson, E. M.. Lam, R. K., Wang, Q., Bo, Ye H., Wilson, E. N., Minhas, P. S., Liu,L., Swarovski, M. S., Tran, S., Wang, J., Mehta, S. S., Yang, X., Rabinowitz, J. D., Yang, S. S., Shamloo, M., Mueller, C., James, M. L., Andreasson, K. I. (2019) . Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severityNat Metab., 20: 1023-1034.

211. Jang, C., Hui, S., Zeng, X., Cowan, A. J., Wang, L., Chen, L., Morscher, R. J., Reyes, J., Frezza,C., Hwang, H. Y., Imai, A., Saito, Y., Okamoto, K., Vaspoli, C., Kasprenski, L., Zsido, G. A. 2nd, Gorman, J. H. 3rd, Gorman, R. C., Rabinowitz, J. D. (2019) Metabolite exchange between mammalian organs quantified in pigs. Cell Metab., 30: 594-606.

210. Song, Y., Park, J. O., Tanner, L., Nagano, Y., Rabinowitz, J. D., Shvartsman, S. Y. (2019) Energy budget of Drosophila embryogenesis. Curr Biol., 29: R566-R567.

209. Schober, A. F., Mathis, A. D., Ingle, C., Park, J. O., Chen, L., Rabinowitz, J. D., Junier, I., Rivoire, O., Reynolds, K. A. (2019) A two-enzyme adaptive unit within bacterial folate metabolism. Cell Rep., 27: 3359-3370.e7.

208. García-Cañaveras, J. C., Chen, L., Rabinowitz, J. D. (2019) The tumor metobolic microenvironment: Lessons from lactate. Cancer Res., 79: 3155-3162.

207. Wang, W., Ishibashi, J., Trefely, S., Shao, M., Cowan, A. J., Sakers, A., Lim, H. W., O'Connor, S., Doan, M. T., Cohen, P., Baur, J. A., King, M. T., Veech, R. L., Won, K. J., Rabinowitz, J. D., Snyder, N. w., Gupta, R. K., Seale, P. (2019) A PRDM 16-driven metabolic signal from adipocytes regulates precursor cell fate. Cell Metab., 30: 174-189.

206. Chen, L., Zhang, Z., Hoshino, A., Zhang, H. D., Morley, M., Arany, Z., Rabinowitz, J. D. (2019) NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat. Metab., 1: 404-415.

205. Bradley, P. H., Gibney, P. A., Botstein, D., Troyanskaya, O. G., Rabinowitz, J. D. (2019) Minor isozymes tailor yeast metabolism to carbon availability. mSystems, 4(1) pii: e00170-18.

204. Rodriguez, A. E., Ducker, G. S., Billingham, L. K., Martinez, C. A., Mainolfi, N., Suri, V., Friedman, A., Manfredi, M. G., Weinberg, S. E., Rabinowitz, J. D., Chandel, N. S. (2019) Serine metabolism supports macrophage IL-1β . Cell Metab., 29: 1003-1011.

203. Wang, L., Xing, X., Chen, L., Yang, L., Su, X., Rabitz, H. A., Lu, W., Rabinowitz, J. D. (2018) Peak annotation and verification engine (PAVE) for untargeted LC-MS metabolomics. Anal. Chem., 91: 1838-1846.

202. Rabinowitz, J. D. and Mutlu, G. M. (2019) A metabolic strategy to reverse fibrosis? Nat Metab, 1: 12-13.

201. Ron-Harel, N., Notarangelo, G., Ghergurovich, J. M., Paulo, J. A., Sage, P. T., Santos, D., Satterstrom, F. K., Gygi, S. P., Rabinowitz, J. D., Sharpe, A. H., Haigis, M. C. (2018) Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci USA, 115: 13347-13352.

200. Minhas, P. S., Liu, L., Moon, P. K., Joshi, A. U., Dove, C., Mhatre, S. Contrepois, K., Wang, Q., Lee, B. A., Coronado, M., Bernstein, D., Snyder, M. P., Migaud, M., Majeti, R., Mochly-Rosen, D., Rabinowitz, J. D., Andreasson, K. I. (2018) Macrophage de novo NAD+ synthesis specifies immune fundtion in aging and inflammation. Nat Immunol., 20: 50-63.

199. Neinast, M. D.,Jang, C., Hui, S., Murashige, D. S., Chu, Q., Morscher, R. J., Li, X., Zhan, L., White, E., Anthony, T. G., Rabinowitz, J. D., Arany, Z. (2018) Quantitative analysis of the whole-body metabolic fate of branched-chain amino acids. Cell Metab., 29: 417-429e4.

198. Poillet-Perez, L., Xie, X., Zhan, L., Yang, Y., Sharp, D. W., Hu, Z. S., Su, X., Maganti, A., Jiang, C., Zheng, H., Bosenberg, M. W., Mehnert, J. M., Guo, J. Y., Lattime, E., Rabinowitz, J. D., White, E. (2018) Autophagy maintains tumour growth through circulating arginine. Nature, 563: 569-573.

197. Xu, Y. F., Lu, W., Chen, J. C., Johnson, S. A., Gibney, P. A., Thomas, D. G., Brown, G., May, A. L., Campagna, S. R., Yakunin, A. F., Botstein, D., Rabinowitz, J. D. (2018) Discovery and functional characterization of a yeast sugar alcohol phosphatase. ACS Chem. Biol.. 13: 3011-3020.

196. Hui, S., Rabinowitz, J. D. (2018) An unexpected trigger for calorie burning in brown fatNature, 560: 38-39.

195. Guan, D., Xiong, Y., Borck, P. C., Jang, C., Doulias, P. T., Papazyan, R., Fang, B., Jiang, C., Zhang, Y., Briggs, E. R., Hu, W., Steger, D., Ischiropoulos, H., Rabinowitz, J. D., Lazar, M. A. (2018) Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic ProcessesCell, 174: 831-842.e12.

194. Li, S. H., Li, Z., Park, J. O., King, C. G., Rabinowitz, J. D., Wingreen, N. S., Gitai, Z. (2018) Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions. Nat Microbiol., 3: 939-947.

193. Rodan, L. H., Qi, W., Ducker, G. S., Demirbas, D., Laine, R., Yang, E., Walker, M. A., Eichler, F., Rabinowitz, J. D., Anselm, I., Berry, G. T., Undiagnosed Diseases Network (UDN). (2018) 5, 10-methenyltetrahydrofolate synthetase deficiency causes a neurometabolic disorder associated with microcephaly, epilepsy, and cerebral hypomyelination. Mol Genet Metab., 125: 118-126.

192. Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E., Rabinowitz, J. D. (2018) Four key steps control glycolytic flux in mammalian cells. Cell Syst., 7: 49-62e8.

191. Davila, A., Liu, L., Chellappa, K., Redpath, P., Nakamaru-Ogiso, E., Paolella, L. M., Zhang, Z., Migaud, M. E., Rabinowitz, J. D., Baur, J. A. (2018) Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife, 7: pii: e33246.

190. Nofal, M. and Rabinowitz, J. D. (2018) Ribosomes on the night shift. Science, 360: 710-711.

189. Jang, C., Chen, L., Rabinowitz, J. D. (2018) Metabolomics and isotope tracing. Cell, 173: 822-837.

188. Liu, L., Su, X., Quinn, W. J. 3rd, Hui, S., Krukenberg, K., Frederick,D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., Migaud, M., Mitchison, T. J., Baur, J. A., Rabinowitz, J. D. (2018) Quantitative analysis of NAD synthesis-breakdown fluxes. Cell Metab., 27: 1067-1080 e5.

187. Miller, R. A., Shi, Y., Lu, W., Pirman, D. A., Jatkar, A., Blatnik, M., Wu, H., Cárdenas, C., Wan, M., Foskett, J. K., Park, J. O., Zhang, Y., Holland, W. L., Rabinowitz, J. D., Birnbaum, M. J. (2018) Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat. Med., 24: 518-524.

186. Lanaspa, M. A., Andres-Hernando, A., Orlicky, D. J., Cicerchi, C., Jang, C., Li, N., Milagres, T., Kuwabara, M., Wempe, M. F., Rabinowitz, J. D., Johnson, R. J., Tolan, D. R. (2018) Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sesitive mice. J. Clin. Invest., 128: 2226-2238.

185. Gibney, P. A., Schieler, A., Chen, J. C., Bacha-Hummel, J. M., Botstein, M., Volpe, M. Silverman, S. J., Xu, Y., Bennett, B. D., Rabinowitz, J. D., Botstein, D. (2018) Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Mol. Biol. Cell, 29: 897-910.

184. McKee, S. E., Zhang, S., Chen, L., Rabinowitz, J. D., Reyes, T. (2018) Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain. J. Neurochem., 145: 362-373.

183. Jang, C. J., Hui, S., Lu, W., Cowan, A. J., Morscher, R. J., Lee, G., Liu, W., Tesz, G. J., Birnbaum, M. J., Rabinowitz, J. D. (2018) The small intestine converts dietary fructose into glucose and organic acids. Cell Metab., 27: 351-361.

182. Morscher, R. J., Ducker, G. S., Li, S. H., Mayer, J. A., Gitai, Z., Sperl, W., Rabinowitz, J. D. (2018) Mitochondrial translation requires folate-dependent tRNA methylationNature, 554: 128-132.

181. Pavlova, N. N., Hui, S., Ghergurovich, J. M., Fan, J., Intlekofer, A. M., White, R. M., Rabinowitz, J. D., Thompson, C. B., Zhang, J. (2018) As extracellular glutamine levels decline, asparagine becomes an essential amino acidCell Metab., 27: 428-438.e5.

180. Lin, K. C., Torga, G., Wu, A., Rabinowitz, J. D., Murray, W. J., Sturm, J. C., Pienta, K. J., Austin R. (2017) Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape. Converg. Sci. Phys. Oncol., 3: pii: 045001.

179. Rebecca, V. W., Nicastri, M. C., McLaughlin, N., Fennelly, C., McAfee, Q., Ronghe, A., Nofal, M., Lim, C. Y., Witze, E., Chude, C. I., Zhang, G., Alicea, G. M., Piao, S., Murugan, S., Ojha, R., Levi, S. M., Wei, Z., Barber-Rotenberg, J. S., Murphy, M. E., Mills, G. B., Lu, Y., Rabinowitz, J., Marmorstein, R., Liu, Q., Liu, S., Xu, X., Herlyn, M., Zoncu, R., Brady, D. C., Speicher, D. W., Winkler, J. D., Amaravadi, R. K. (2017) A unified approach to targeting the lysosome's degradative and growth signaling roles. Cancer Discov., 7: 1266-1283.

178. Lee, G., Zheng, Y., Cho, S., Jang, C.,England, C., Dempsey, J. M., Yu, Y., Liu, X., He, L., Cavaliere, P. M., Chavez, A., Zhang, E., Isik, M., Couvillon, A., Dephoure, N. E., Blackwell, T. K., Yu, J. J., Rabinowitz, J. D., Cantley, L. C., Blenis, J. (2017) Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signalingCell, 171: 1545-1558.

177. Ducker, G. S., Ghergurovich, J. M., Mainolfi, N., Suri, V., Jeong, S. K., Hsin-Jung, Li S., Friedman, A., Manfredi, M. G., Gitai, Z., Kim, H., Rabinowitz, J. D. (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphomaProc. Natl. Acad. Sci. USA, 114: 11404-11409.

176. Hui, S., Ghergurovich, J. M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Le, Z., Yanxiang Guo, J., White, E., Rabinowitz, J. D. (2017) Glucose feeds the TCA cycle via circulating lactateNature, 551: 115-118.

175. Wooldridge, A. L., Bischof, R. J., Liu, H., Heinemann, G. K., Hunter, D. S., Giles, L. C., Simmons, R. A., Lien, Y. C., Rabinowitz, J. D., Kind, K. L., Owens, J. A., Clifton, V. L., Gatford, J. L. (2017) Late gestation maternal dietary methyl donor and cofactor supplementation in sheep partially reverses protection against allergic sensitization by IUGRAm. J. Physiol. Regul. Integr. Comp. Physiol, 314: R22-R33.

174.Liu, L. X., Rowe, G. C., Yang, S., Li. J., Damilano, F., Chan, M. C., Lu, W., Jang, C., Wada, S., Morley, M., Hesse, M., Fleischmann, B. K., Rabinowitz, J., Das, S., Rosenzweig, A., Arany, Z. (2017) PDK4 inhibits cardiac pyruvate oxidation in late pregnancyCir. Res., 121: 1370-1378.

173. Kim, H. I., Raffler, J., Lu, W., Lee, J. J., Abbey, D., Saleheen, D., Rabinowitz, J. D., Bennett, M. J., Hand, N. J., Brown, C., Rader, D. J. (2017) Fine mapping and functional analysis reveal a role of SLC22A1 in acylcarnitine transportAm. J. Hum. Genet., 101: 489-502.

172. Nofal, M., Zhang, K., Han, S., Rabinowitz, J. D. (2017) mTOR inhibition restores amino acid balance in cells dependent on catabolism of extracellular proteinMol. Cell, 67: 936-945.e5.

171. Zhang, Z., Chen, L., Liu, L., Su, X., Rabinowitz, J. D. (2017) Chemical basis for deuterium labeling of fat and NADPHJ Am Chem Soc, 139: 14368-14371. 

170. Zhang, Y., Kurupati, R., Liu, L., Zhou, X. Y., Zhang, G., Hudaihed, A., Filisio, F., Giles-Davis, W., Xu, X., Karakousis, G. C., Schuchter, L. M., Xu, W., Amaravadi, R., Xiao, M., Sadek, N., Krepler, C., Herlyn, M., Freeman, G. J., Rabinowitz, J. D., Ertl, H. C. J. (2017) Enhancing CD8+ T cell fatty acid catabolism within a metabolically challenging tumor microenvironment increases the efficacy of melanoma immunotherapyCancer Cell, 32: 377-391.e9.

169. Chen, L., Ducker, G. S., Lu, W., Teng, X., Rabinowitz, J. D. (2017) An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolateAnal. Bioanal. Chem., 409: 5955-5964.

168. Oslund, R. C., Su, X., Haugbro, M., Kee, J. M., Esposito, M., David, Y., Wang, B., Ge, E., Perlman, D. H., Kang, Y., Muir, T. W., Rabinowitz, J. D. (2017) Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerateNat. Chem. Biol., 13: 1081-1087.

167. Song, Y., Marmion, R. A., Park, J. O., Biswas, D., Rabinowitz, J. D., Shvartsman, S. Y. (2017) Dynamic control of dNTP synthesis in early embryos. Dev. Cell., 42: 301-308.e3,

166. Lu, W., Su, X., Klein, M. S., Lewis, I. A., Fiehn, O., Rabinowitz, J. D. (2017) Metabolite measurement: Pitfalls to avoid and practices to followAnnu. Rev. Biochem., 86: 277-304.

165. Rajeshkumar, N. V., Yabuuchi, S., De Oliveira, E., Kamphorst, J. J., Rabinowitz, J. D., Tejero, H., Al-Shahrour, F., Hidalgo, M., Maitra, A., Dang, C. V. (2017) Treatment of pancreatic cancer patient-derived xenograft panel with metabolic inhibitors reveals efficacy of phenforminClin. Cancer Res., 23: 5639-5647.

164. Gong, Y., Cao, R., Ding, G., Hong, S., Zhou, W., Lu, W., Damle, M., Fang, B., Wang, C. C., Qian, J., Lie, N., Lanzillotta, C., Rabinowitz, J. D., Sun, Z. (2017) Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscleMol. Cell Endocrinol., 471: 22-32.

163. Choi, J., Rajagopal, A. Xu, Y. F., Rabinowitz, J. D., O'Shea, E. K. (2017) A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiaePLoS One, 12: e0176085.

162. Lu, W., Wang, L., Chen, L., Hui, S., Rabinowitz, J. D. (2017) Extraction and quantitation of NAD redox cofactorsAntioxid. Redox Signal, 28: 167-179.

161. Su, X., Lu, W., Rabinowitz, J. D. (2017) Metabolite spectral accuracy on orbitrapsAnal. Chem., 89: 5940-5948.

160. Davidson, S. M., Jonas, O., Keibler, M. A., Hou, H. W., Luengo, A., Mayers, J. R., Wyckoff, J., Del Rosario, A. M., Whitman, M., Chin, C. R., Condon, K. J., Lammers, A., Kellersberger, K. A., Stall, B. K., Stephanopoulos, G., Bar-Sagi, D., Han, J., Rabinowitz, J. D., Cima, M. J., Langer, R., Vander Heiden, M. G. (2016) Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumorsNat. Med., 23: 235-241.

159. Hong S., Zhou, W., Fang, B., Lu, W., Loro, E., Damle M., Ding, G., Jager, G., Zhang, S., Zhang, Y., Feng, D., Chu, Q., Dill, B. D., Molina, H., Khurana, T. S., Rabinowitz, J. D.,Lazar, M. A., Sun, Z. (2016) Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletionNat. Med., 23: 223-234.

158. Papazyan, R., Sun, Z., Kim, Y. H., Titchenell,P. M., Hill, D. A., Lu, W., Damle, M., Wan, M., Zhang, Y., Briggs, E. R., Rabinowitz, J. D., Lazar, M. A. (2016) Physiological suppression of lipotoxic liver damage by complementary actions of HDAC3 and SCAP/SREBPCell Metab., 24: 863-874.

157. Hackett, S. R., Zanotelli, V. R., Xu, W., Goya, J., Park, J. O., Perlman, D. H., Gibney, P. A., Botstein, D., Storey, J. D., Rabinowitz, J. D. (2016) Systems-level analysis of mechanisms regulating yeast metabolic fluxScience, 354: aaf2786.

156. Ducker, G. S. and Rabinowitz, J. D. (2016) One-carbon metabolism in health and diseaseCell Metab., 25: 27-42..

155. Moloughney, J. G., Kim, P. K., Vega-Cotto, N. M., Wu, C. C., Zhang, S., Adlam, M., Lynch, T., Chou, P. C., Rabinowitz, J. D., Werlen, G., Jacinto, E. (2016) mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1Mol. Cell, 63: 811-26.

154. Guo, J. Y., Teng, X., Laddha, S. V., Ma, S., Van Nostrand, S. C., Yang, Y., Khor, S., Chan, C. S., Rabinowitz, J. D., White, E. (2016) Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cellsGenes Dev., 30: 1704-17.

153. Frederick, D. W., Loro, E., Liu, L., Davila, A. Jr.,Chellappa, K., Silverman, I. M., Quinn, W. J. 3rd, Gosai, S. J., Tichy, E. D., Davis, J. G., Mourkioti, F., Gregory, B. D., Dellinger, R. W., Redpath, P., Migaud, M. E., Nakamaru-Ogiso, E., Rabinowitz, J. D., Khurana, T. S., Baur, J. A. (2016) Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscleCell Metab., 24: 269-82.

152. Ron-Harel, N., Santos, D., Ghergurovich, J. M., Sage, P. T., Reddy, A., Lovitch, S. B., Dephoure, N., Satterstrom, F. K., Sheffer, M., Spinelli, J. B., Gygi, S., Rabinowitz, J. D., Sharpe, A. H., Haigis, M. C. (2016) Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activationCell Metab. 24: 104-107.

151.Teng, X., Emmett, M. J., Lazar, M. A., Goldberg, E., Rabinowitz, J. D. (2016) Lactate dehydrogenase C produces S-2-Hydroxyglutarate in mouse testisACS Chem. Biol., 11: 2420-7.

150. Titchenell, P. M., Quinn, W. J., Lu, M., Chu, Q., Lu, W., Li, C., Chen, H., Monks, B, R., Chen, J., Rabinowitz, J. D., Birnbaum, M. J. (2016) Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose productionCell Metab., 23: 1154-66. 

149. Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., Rabinowitz, J. D. (2016) Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathwayCell Metab., 23: 1140-53. 

148. Park, J. O., Rubin, S. A., Xu, Y. F., Amador-Noguez, D., Fan, J., Shlomi, T., Rabinowitz, J. D. (2016) Metabolite concentrations, fluxes and free energies imply efficient enzyme usageNat. Chem. Biol., 12: 482-9.

147. Bren, A., Park, J. O., Towbin, B. D., Dekel, E., Rabinowitz, J. D., Alon, U. (2016) Glucose becomes one of the worst carbon sources for E. coli on poor nitrogen sources due to suboptimal levels of cAMPSci. Rep., 6: 24834.

146. Rabinowitz, J. D., Coller, H. A. (2016) Partners in the Warburg effectElife, 5: e15938.

145. Liu, L., Shah, S., Fan, J., Park, J. O., Wellen, K. E., Rabinowitz, J. D. (2016) Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usageNat. Chem. Biol., 12: 345-52.

144. Koivunen, P., Fell, S. M., Lu, W., Rabinowitz, J. D., Kung, A. L., Schlisio, S. (2016) The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor 1α in cancer cells, induces cell death, and reduces tumor xenograft growthHypoxia, 4: 15-27. 

143. Jang, C., Oh, S. F., Wada, S., Rowe, G. C., Liu, L., Chan, M. C., Rhee, J., Hoshino, A., Kim, B., Ibrahim, A., Baca, L. G., Kim, E., Ghosh, C. C., Parikh, S. M., Jiang, A., Chu, Q., Forman, D. E., Lecker, S. H., Krishnaiah, S., Rabinowitz, J. D., Weljie, A. M., Baur, J. A., Kasper, D. L., Arany, Z. (2016) A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistanceNat. Med., 22: 421-6.

142. Zong, W. X., Rabinowitz, J. D., White, E. (2016) Mitochondria and cancerMol. Cell, 61: 667-76.

141. Su, X., Wellen, K. E., Rabinowitz, J. D. (2016) Metabolic control of methylation and acetylationCurr. Opin. Chem. Biol., 30: 52-60.

140. Bott, A. J., Peng, I. C., Fan, Y., Faubert, B., Zhao, L., Li, J., Neidler, S., Sun, Y., Jaber, N., Krokowski, D., Lu, W., Pan, J. A., Powers, S., Rabinowitz, J., Hatzoglou, M., Murphy, D. J., Jones, R., Wu, S., Girnun, G., Zong, W. X. (2015) Oncogenic Myc induces expression of glutamine synthetase through promoter demethylationCell Metab., 22: 1068-77.

139. Mok, W. W., Park, J. O., Rabinowitz, J. D., Brynildsen, M. P. (2015) RNA futile cycling in model persisters derived from MazF accumulationMBio, 6: e01588-15.

138. Rajeshkumar, N. V., Dutta, P., Yabuuchi, S., de Wilde, R. F., Matrinez, G. V., Le, A., Kamphorst, J. J., Rabinowitz, J. D., Jain, S. K., Hidalgo, M., Dang, C. V., Gillies, R. J., Maitra, A. (2015) Therapeutic targeting of the Warburg effect in pancreatic cancer relies on an absence of p53 functionCancer Res., 75: 3355-64.

137. Gibney, P. A., Schieler, A., Chen, J. C., Rabinowitz, J. D., Botstein, D. (2015) Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporterProc. Natl. Acad. Sci. USA, 112: 6116-21.

136. Purdy, J. G., Shenk, T., Rabinowitz, J. D. (2015) Fatty Acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replicationCell Rep., 10: 1375-85. 

135. Buescher, J. M., et. al. (2015) A roadmap for interpreting 13C metabolite labeling patterns from cellsCurr. Opin. Biotechnol., 34: 189-201.

134. Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka,E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., Thompson, C. B., Rabinowitz, J. D. (2015) Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular proteinCancer Res., 75: 544-53.

133. Ducker, G. S. and Rabinowitz, J. D. (2015) ZMP: A master regulator of one-carbon metabolismMol. Cell, 57: 203-4.

132. Xu, Y. F., Lu, W., Rabinowitz, J. D. (2015) Avoiding misannotation of in-source fragmentation products as cellular metabolites in liquid chromatography-mass spectrometry-based metabolomesAnal. Chem., 87: 2273-81.

131. Aristilde, L., Lewis, I. A., Park, J. O., Rabinowitz, J. D. (2014) Hierarchy in pentose sugar metabolism in clostridium acetobutylicumAppl. Environ. Microbiol., 81: 1452-62. 

130. Hwang, J., Purdy, J. G., Wu, K., Rabinowitz, J. D., Shenk, T. (2014) Estrogen-related receptor α is required for efficient human cytomegalovirus replicationProc. Natl. Acad. Sci. USA, 111: E5706-17.

129. Kamphorst, J. J., Chung, M. K., Fan, J., Rabinowitz, J. D. (2014) Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer & Metabolism, 2: 23.

128. Fan, J., Teng, X., Liu, L., Mattaini, K. R., Looper, R. E., Vander Heiden, M. G., Rabinowitz, J. D. (2014) Human phosphoglycerate dehydrogenase produces the oncometabolite d-2-hydroxyglutarateACS Chem Biol., 10: 510-6.

127. Castellana, M., Wilson, M. Z., Xu, Y., Joshi, P., Cristea, I. M., Rabinowitz, J. D., Gitai, Z., Wingreen, W. S. (2014) Enzyme clustering accelerates processing of intermediates through metabolic channelingNat. Biotechnol., 32: 1011-8. 

126. Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M., Campbell, K., Cheung, E., Olin-Sandoval, V., Gruening, N. M., Krueger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D., Raiser, M. (2014) The return of metabolism: biochemistry and physiology of the pentose phosphate pathwayBiol. Rev. Camb. Philos. Soc., 90: 927-63.

125. Zhang, J., Fan, J., Venneti, S., Cross, J. R., Takagi, T., Bhinder, B., Djaballah, H., Kanai, M., Cheng, E. H., Judkins, A. R., Pawel, B., Baggs, J., Cherry, S., Rabinowitz, J. D., Thompson, C. B. (2014) Asparagine plays a critical role in regulating cellular adaptation to glutamine depletionMol. Cell, 56: 205-18.

124. Ye, J., Fan, J., Venneti, S., Wan, Y. W., Pawel, B. R., Zhang, J., Finley, L. W., Lu, C., Linsten, T., Cross, J., Qing, G., Liu, Z., Simon, M. C., Rabinowitz, J. D., Thompson, C. (2014) Serine catabolism regulates mitochondrial redox control during hypoxiaCancer Discov., 4: 1406-17. 

123. Mathew, R., Khor, S., Hackett, S. R., Rabinowitz, J. D., Perlman, D. H., White, E. (2014) Functional role of autophagy-mediated proteome remodeling in cell survival signaling and innate immunityMol. Cell, 55: 916-30.

122. Karsli-Uzunbas, G., Guo, J. Y., Price, S. M., Teng, X., Laddha, S. V., Khor, S., Kalaany, N. Y., Jacks, T., Chan, C. S., Rabinowitz, J. D., White, E. (2014) Autophagy is required for glucose homeostasis and lung tumor maintenanceCancer Discov., 4: 914-27. 

121. Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., Rabinowitz, J. D. (2014) Quantitative flux analysis reveals folate-dependent NADPH productionNature, 510: 298-302.

120. Breunig, J. S., Hackett, S. R., Rabinowitz, J. D., Krugkyak, L. (2014) Genetic basis of metabolome variation in yeastPLoS Genet., 10: e1004142.

119. Shlomi, T., Fan, J., Tang, B., Kruger, W. D., Rabinowitz, J. D. (2014) Quantitation of cellular metabolic fluxes in methionineAnal. Chem., 86: 1583-91.

118. Kliegman, J. I., Fiedler, D., Ryan, C. J., Xu, Y. F., Su, X. Y., Thomas, D., Caccese, M. C., Cheng, A., Shales, M., Rabinowitz, J. D., Krogan, N. J., Shokat, K. M. (2013) Chemical genetics of rapamycin-insensitive TORC2 in s. cerevisiaeCell Rep., 5: 1725-36.

117. Fan, J., Kamphorst, J. J., Mathew, R., Chung, M. K., White, E., Shlomi, T., Rabinowitz, J. D. (2013) Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxiaMol. Syst. Biol., 9: 712.

116. Grady, S. L., Purdy, J. G., Rabinowitz, J. D., Shenk, T. (2013) Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infectionProc. Natl. Acad. Sci. USA, 110: E5006-15.

115. Tchigvintsev, A., Tchigvintsev, D., Flick, R., Popovic, A., Dong, A., Xu, X., Brown, G., Lu, W., Wu, H., Dombrowski, L., Joo, J. C., Beloglazova, N., Min, J., Savchenko, A., Caudy, A. A., Rabinowitz, J. D., Murin, A. G., Yakunin, A. F. (2013) Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.Chem. Biol., 20: 1386-98.

114. Tepper, N., Noor, E., Amador-Noguez, D., Haraldsdóttir, H. S., Milo, R., Rabinowitz, J.,Liebermeister, W., Shlomi, T. (2013) Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite loadPLoS One, 8: e75370.

113. Fan, J., Kamphorst, J. J., Rabinowitz, J. D., Shlomi, T. (2013) Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive IDH flux. J. Biol. Chem., 288: 31363-9.

112. Rabinowitz, J. D. and Silhavy, T. J. (2013) Systems biology: metabolite turns master regulatorNature, 500: 283-4.

111. Reaves, M.L., Young, B. D., Hosios, A. M., Xu, Y. F., Rabinowitz, J. D. (2013) Pyrimidine homeostasis is accomplished by directed overflow metabolismNature, 500(7461): 237-41.

110. Guo, L. Y., Karsli-Uzunbas, G., Mathew, R., Aisner, S. C., Kamphorst, J.J., Strohecker, A. M., Chen, G., Price, S., Lu, W., Teng, X., Snyder, E., Santanam, U., Dipaola, R. S., Jacks, T., Rabinowitz, J. D., White, E. (2013) Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasisGenes Dev., 27: 1447-61.

109. Koyuncu, E., Purdy, J. G., Rabinowitz, J. D., Shenk, T. (2013) Saturated very long fatty acids are required for the production of infectious human cytomegalovirus progenyPLoS Pathog., 9: e1003333. 

108. Kamphorst, J. J., Cross, J. R., Fan, J., de Stanchina, E., Mathew, R., White, E. P., Thompson, C. B., Rabinowitz, J. D. (2013) Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipidsProc. Natl. Acad. Sci. USA, 110: 8882-7. 

107. Xu, Y. F., Létisse, F., Absalan, F., Lu, W., Kuznetsova, E., Brown, G., Caudy, A. A., Yakunin, A. F., Broach, J. R., Rabinowitz, J. D. (2013) Nucleotide degradation and ribose salvage in yeastMol. Syst. Biol., 9: 665.

106. Commiso, C., Davidson, S. M., Soydaner-Azeloglu, R. g., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., Rabinowitz, J. D., Metallo, C. M. (2013) Macropinocytosis of protein is an amino acid supply route in Ras-transformed cellsNature, 497: 633-7.

105. Shlomi T. and Rabinowitz, J. D. (2013) Metabolism: Cancer mistunes methylationNat. Chem. Biol., 9: 293-4. 

104. Xu, Y. F., Zhao, X., Glass, D. S., Absalan, F., Perlman, D. H., Broach, J. R., Rabinowitz, J. D. (2012) Regulation of yeast pyruvate kinase by ultrasensitive allostery independent of phosphorylationMol. Cell, 48: 52-62. 

103. Bray, K., Mathew, R., Lau, A., Kamphorst, J. J., Fan, J., Chen, J., Chen, H. Y., Ghavami, A., Stein, M., Dipaola, R. S., Zhang, D., Rabinowitz, J. D., White, E. (2012) Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibitionPLoS One, 7: e41831. 

102. Reaves, M. L., Sinha, S., Rabinowitz, J. D., Kruglyak, L., Redfield, R. J. (2012) Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cellsScience, 337: 470-3.

101. Grady, S. L., Hwang, J., Vastag, L., Rabinowitz, J. D., Shenk, T. (2012) Herpes simplex virus type 1 infection activates poly (ADP-ribose) polymerase and triggers the degradation of poly (ADP-ribose) glycohydrolaseJ. Virol., 86: 8259-68. 

100. Rabinowitz, J. D. and Vastag, L. (2012) Teaching the design principles of metabolism. Nat. Chem.Biol., 8:497-501.

99. Xu, Y., Amador-Noguez, D., Reaves, M. L., Feng, X. J., Rabinowitz, J. D. (2012) Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylaseNat. Chem. Biol., 8: 562-68.   

98.  Ye, J., Mancuso, A., Tong, X., Ward, P. S., Fan, J., Rabinowitz, J. D., Thompson, C. B. (2012). Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferationProc. Natl. Acad. Sci. USA, 109: 6904-09.

97. Peterson, C. N., Levchenko, I., Rabinowitz, J. D., Baker, T. A., Silhavy, T. J. (2012). RpoS proteolysis is controlled directly by ATP levels in Escherichia coliGenes Dev., 26: 548-53.

96. Clasquin, M. F, Melamud, E., Rabinowitz, J. D. (2012). LC-MS Data Processing with MAVEN: A Metabolomic Analysis and Visualization EngineCurr. Protoc. Bioinformatics, 14: Unit14.11.

95. Terry, L. J., Vastag, L., Rabinowitz, J. D., Shenk, T. (2012). Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Proc. Natl. Acad. Sci. USA, 109:3071-6. 

94. Rabinowitz, J. D., Purdy, J. G., Vastag, L., Shenk, T., Koyuncu, E. (2011).Metabolomics in drug target discoveryCold Spring Harb. Symp. Quant. Biol., 76: 235-46.

93. Kamphorst, J. J., Fan, J., Lu, W., White, E., Rabinowitz, J. D. (2011). Liquid chromatography-high resolution mass spectrometry analysis of fatty acid metabolismAnal. Chem., 83: 9114-22.  

92. Doucette, C. D., Schwab, D. J., Wingreen, N. S., Rabinowitz, J. D. (2011). α-Ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibitionNat. Chem. Biol., 7: 894-901. 

91. Amador-Noguez, D. Brasg, I. A., Feng, X. J., Roquet, N., Rabinowitz, J. D. (2011). Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicumAppl. Environ. Microbiol., 77: 7984-97.  

90. Strelko, J. L., Lu, W., Dufort, F. J., Seyfried, T. N., Chiles, T. C., Rabinowitz, J. D., Roberts, M. F. (2011). Itaconic acid is a mammalian metabolite induced during macrophage activationJ. Am. Chem. Soc., 133: 16386-9. 

89. Vastag, L., Koyuncu, E., Grady, S. L., Shenk, T. E., Rabinowitz, J. D. (2011). Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolismPLoS Pathog., 7: e1002124. 

88.  Liu, S. T. H., Sharon-Frilling, R., Ivanova, P., Milne, S. B., Myers, D. S., Rabinowitz, J. D., Brown, H. A., Shenk, T. (2011). Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egressPNAS, 108: 12869-74. 

87. Petti, A. A., Crutchfield, C. A., Rabinowitz, J. D., Botstein, D. (2011). Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial functionProc. Natl. Acad. Sci. USA, 108: E1089-98.  

86. Clasquin, M. F., Melamud, E., Singer, A., Gooding, J. R., Xu, X., Dong, A., Cui, H., Campagna, S. R., Savchenko, A., Yakunin, A. F., Rabinowitz, J. D., Caudy, A. A. (2011). Riboneogenesis in yeastCell, 145: 969-980.

85. Reaves, M. L. and Rabinowitz, J. D. (2011). Characteristic phenotypes associated with ptsN-null mutants in Escherichia coli K-12 are absent in strains with functional ilvGJ. Bacteriol., 193: 4676-81.  

84. Guo, J. X., Chen, H.Y., Mathew, R., Fan, J., Strohecker, A, M., Karsli-Uzunbas, G., Kamphorst, J. J., Chen, G., Lemmons, J. M. S., Karantza, V., Coller, H. A., DiPaola, R. S., Gelinase, C., Rabinowitz, J. D., White, E. (2011). Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesisGenes & Dev., 25460-470. 

83. Klosinska, M. M., Crutchfield, C., Bradley, P. J., Rabinowitz, J. D., Broach, J. R. (2011). Yeast cells can access distinct  quiescent statesGenes Dev., 25: 336-49. 

82. Vastag, L., Jorgensen, P., Peshkin, L., Rabinowitz, J. D., Kirschner, M. W. (2011). Remodeling of the metabolome during early frog developmentPLoS ONE, 6: e16881.

81. Hart, Y., Madar, D., Yuan, J., Bren, A., Mayo, A. E., Rabinowitz, J. D., Alon, U. (2011) Robust control of nitrogen assimilation by a bifunctional enzyme in E. coliMol. Cell, 41: 117-127.

80. Merritt, J. H., Ha, D.G., Cowles, K. N., Lu, W., Morales, D. K., Rabinowitz, J., Gitai, Z., O’Toole, G. A. (2010). Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclasesmBio, 1: pii. e00183-10.

79. Wellen, K. E., Lu, Lu, C., Mancuso, A., Lemons, J. M., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., Thompson, C. B. (2010). The hexosamine biosynthetic pathwaycouples growth factor -induced glutamine uptake to glucose metabolismGenes Dev., 24: 2784-2799.  

78. Rabinowitz, J. D. and White, E. (2010). Autophagy and metabolismScience, 330: 1344-8.

77. Melamud, E., Vastag, L., Rabinowitz, J. D. (2010) Metabolomic analysis and visualization engine for LC-MS dataAnal. Chem., 82: 9818-9826.

76. Seltzer, M. J., Bennett, B. D., Joshi, A. D., Gao, P., Thomas, A. G., Ferraris, D. V., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Rabinowitz, J. D., Dang, C. V., Riggins, G. L. (2010). Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1Cancer Res., 70: 8981-7. 

75. Reaves, M. L. and Rabinowitz, J. D. (2010) Metabolomics in systems microbiologyCurr. Opin. Biotechnol., 22: 17-25. 

74. Lemons, J. M. S., Feng, X. J., Bennett, B. D., Legesse-Miller, A., Johnson, E. L., Raitman, I., Pollina, E. A., Rabitz, H. A., Rabinowitz, J. D., Coller, H. A. (2010). Quiescent fibroblasts exhibit high metabolic activityPLoS Biol., 8: e1000514.

73. Vander Heiden, M. G., Locasale, J. W., Swanson, K.D., Sharfi, H., Heffron, G.J., Amador-Noguez, D., Christofk, H. R., Wagner, G., Rabinowitz, J.D., Asara, J.M., Cantley, L.C. (2010) Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating CellsScience, 329: 1492-1499.

72. Amador-Noguez, D., Feng, X. F., Fan, J.,Roquet, N., Rabitz, H., Rabinowitz, J. D. (2010) Systems-level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicumJ. Bacteriol., 192: 4452-4461.

71. Kwon., Y. K., Higgins, M. B., Rabinowitz, J. D. (2010) Antifolate-induced Depletion of Intracellular Glycine and Purines Inhibits Thymineless Death in E. coliACS Chem. Biol., 5: 787-795.

70. Goyal, S., Yuan, J., Chen, T., Rabinowitz, J. D., Wingreen, N. S. (2010) Achieving Optimal Growth through Product Feedback Inhibition in MetabolismPLoS Comput. Biol., 6: e1000802.

69. Goodarzi, H., Bennett, B. D., Amini, S., Reaves, M. L., Hottes, A. K., Rabinowitz, J. D., Tavazoie, S. (2010) Regulatory and Metabolic Rewiring during Laboratory Evolution of Ethanol Tolerance in E. coliMol. Syst. Biol., 6: 378.

68. Crutchfield, C., Lu, W., Melamud, E., Rabinowitz, J. D. (2010)  Mass Spectrometry-Based Metabolomics of YeastMethods Enzymol. 470: 393-426. 

67. Kuchma, S. L., Ballok, A. E., Merritt, J. H., Hammond, J. H., Lu, W., Rabinowitz, J. D., O'Toole, G. A. (2010). Cyclic-di-GMP-Mediated Repression of Swarming Motility by Pseudomonas aeruginosa: The pilY1 Gene and its Impact on Surface-Associated BehaviorsJ. Bacteriol., 192: 2950-64.

66. Lu, W., Clasquin, M. F., Melamud, E., Amador-Noguez, D., Caudy, A. A., Rabinowitz, J. D. (2010) Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometerAnal. Chem., 82: 3212-3221.

65. Monds, R. D., Newell,, P. D., Wagner, J. C., Schwartzman, J. A., Lu, W., Rabinowitz, J. D., O'Toole, G. A. (2010). Di-adenosine tetraphosphate (Ap4A) metabolism impacts biofilm formation by Pseudomonas fluorescens via modulation of c-di-GMP-dependent pathwaysJ. Bacteriol., 192: 3011-23.

64. Ward, P. S., Patel, J., Wise, D. R., Abdel-Wahab, O., Bennett, B. D., Coller, H. A., Cross, J. R., Fantin, V. R., Hedvat, C. V., Perl, A. E., Rabinowitz, J. D., Carroll, M., Su, S. M., Sharp, K. A., Levine, T. L., Thompson, C. B. (2010). The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarateCancer Cell, 17: 215-6. 

63. Lu., X., Bennett, B., Mu, E., Rabinowitz, J., Kang, Y. (2010). Metabolomic changes accompanying transformation and acquisition of metastatic potential in a syngeneic mouse mammary tumor modelJ. Biol. Chem., 285: 9319-21.

62. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., Rabitz, H. A. (2010). A network flow model for biclustering via optimal re-ordering of data matrices. J. Glob. Optim., 47: 343-354. 

61. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Li, G., Rabinowitz, J. D., Rabitz, H. A. (2010). Enhancing molecular discovery using descriptor-free rearrangement clustering techniques for sparse data setsAIChE Journal, 56: 405-418.

60. Boer, V. M., Crutchfield, C. A., Bradley, P. H., Botstein, D., Rabinowitz, J. D. (2010). Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitationsMol. Biol. Cell, 21: 198-211.

59. Dang, L., White, D.W., Gross, S., Bennett, B.D., Bittinger, M.A., Driggers, E.M., Fantin, V.R., Jang, H.G., Jin, S., Keenan, M.C., Marks, M., Prins, R.M., Ward, P.S., Yen, K.E., Liau, L.M., Rabinowitz, J.D., Cantley, L.C., Thompson, C.B., Vander Heiden, M.G., Su, S.M. (2009). Cancer-associated IDH1 mutations produce 2-hydroxyglutarateNature, 462: 739-44.

58.  Kelly, R. C., Bolitho, M. E., Higgins, D. A., Lu, W., Ng, W. L., Jeffrey, P. D., Rabinowitz, J. D., Semmelhack, M. F., Hughson, F. M., Bassler, B. L. (2009) The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsANat. Chem. Biol., 5: 891-5. 

57. Yuan, J., Doucette, C., Fowler, W. U., Feng, X. J., Piazza, M., Rabitz, H. A., Wingreen, N. S., Rabinowitz, J. D. (2009). Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. Mol. Syst. Biol., 5: 302.

56. Bennett, B. D., Kimball, E. H., Gao, M., Osterhout, R., Van Dien, S. J., Rabinowitz, J. D. (2009). Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coliNat. Chem. Biol., 5: 593-9.

55. Olszewski, K. L., Morrisey, J. M., Wilinski, D., Burns, J. M., Vaidya, A. B., Rabinowitz, J. D., Llinás, M. (2009). Host parasite interactions revealed by Plasmodium falciparum metabolomicsCell Host Microbe, 5: 191-9.

54. Shinar, G., Rabinowitz, J. D., Alon, U. (2009). Robustness in glyoxylate bypass regulationPLoS Comp. Biol., 5: e1000297.

53. Bradley, P. H., Brauer, M. J., Rabinowitz, J. D., Troyanskaya, O. (2009). Coordinated concentration changes of transcript and metabolites in Saccharomyces cerevisiae. PLoS Comp. Biol., 5: e1000270.

52. DiMaggio, P. A., McAllister, S. R., Floudas, C. A., Feng, X. J., Rabinowitz, J. D., Rabitz, H. A. (2008). Biclustering via optimal re-ordering of data matrices in systems biology: Novel rigorous methods and comparative studiesBMC Bioinformatics, 9: 458.

51. McAllister, S. R., Feng, X. J., Dimaggio, P. A. Jr., Floudas, C. A., Rabinowitz, J. D., Rabitz, H. (2008). Descriptor-free molecular discovery in large libraries by adaptive substituent reorderingBioorg. Med. Chem. Lett., 18: 5967-5970.

50. Munger, J., Bennett, B. D., Parikh, A., Feng, X. J., McArdle, J., Rabitz, H. A., Shenk, T., Rabinowitz, J. D. (2008). Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for anti-viral therapy. Nat. Biotechnol., 26: 1179-1186.

49. Kwon, Y. K., Lu, W., Melamud, E., Khanam, N., Bognar, A., Rabinowitz, J. D. (2008). A domino effect in antifolate drug action in Escherichia coli. Nat. Chem. Biol., 4: 602-608.

48. Yuan, J., Bennett, B. D., Rabinowitz, J. D. (2008).Kinetic flux profiling for quantitation of cellular metabolic fluxesNat. Protocols, 3: 1328-1340.

47. Bennett, B. D., Yuan, J., Kimball, E. H., Rabinowitz, J. D. (2008). Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approachNat. Protocols, 3: 1299-1311.

46. Lu, W., Bennett, B. D., Rabinowitz, J. D. (2008). Analytical strategies for LC-MS-based targeted metabolomics. J. Chrom. B., 871: 236-242.

45. Waters, C. M., Lu, W., Rabinowitz, J. D., Bassler, B. L. (2008). Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsTJ. Bacteriol., 190: 2527-2536.  

44. Rabinowitz, J. D., Hsiao, J. J., Gryncel, K. R., Kantrowitz, E. R., Feng, X. J., Li, G., Rabitz, H. (2008). Dissecting enzyme regulation by multiple allosteric effectors: Nucleotide regulation of aspartate transcarbamoylase. Biochemistry, 47: 5881-5888.

43. Piazza, M., Feng, X. J., Rabinowitz, J. D., Rabitz, H. (2008). Diverse metabolic model parameters generate similar methionine cycle dynamicsJ. Theor. Biol., 251: 628-639.

42. Cui, H., Hayashi, A., Sun, H. S., Belmares, M. P., Cobey, C., Phan, T., Schweizer, J., Salter, M. W., Wang, Y. T., Tasker, R. A., Garman, D., Rabinowitz, J., Lu, P. S., Tymianski, M. (2007). PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J. Neurosci., 27: 9901-9915.

41. Xavier, K. B., Miller, S. T., Lu, W., Kim, J. H., Rabinowitz, J., Pelczer, I., Semmelhack, M. F., Bassler, B. L. (2007). Phosphorylation and processing of the quorum-sensing molecule AI-2 in enteric bacteriaACS Chem. Biol., 2: 128-136.

40. Yuan, J., Rabinowitz, J. D. (2007). Differentiating metabolites formed from de novo synthesis versus macromolecule decompositionJ. Am. Chem. Soc., 129: 9294-9295. 

39. Rabinowitz, J. D., Kimball, E. (2007). Acidic acetonitrile for cellular metabolome extraction from Escherichia coliAnal. Chem., 79: 6167-6173.

38. Lu, W., Kwon, Y. K., Rabinowitz, J.D. (2007).  Isotope ratio-based profiling of microbial folatesJ. Am. Soc. Mass Spectr., 18: 898-909.  

37. Campagna, S. R., Rabinowitz, J. D. (2007). Metabolome quantitation mass spectrometryG.I.T. Laboratory Journal, 7-8: 26-27.

36. Rabinowitz, J. D. (2007). Cellular metabolomics of Escherichia coli. Exp. Rev. Proteomics, 4: 187-198.

35. Avram, M. J., Henthorn, T. K., Spyker, D. A., Krejcie, T. C., Lloyd, P. M., Cassella, J. V., Rabinowitz, J. D. (2007). Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs. Drug. Metab. Dispos., 35: 262-267.

34. Bao, Q., Lu, W., Rabinowitz, J. D., Shi, Y. (2007). Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1. Mol. Cell, 25: 181-192.

33. Myers, D. J., Timmons, R. D., Lu, A. T., Hale, R. L., Solas, D. W., Soni, P., Rabinowitz, J. D. (2007). Effect of film thickness on thermal aerosol generationPharm. Res., 24: 336-342.

32. Brauer, M. J., Yuan, J., Bennett, B. D., Lu, W., Kimball, E., Botstein, D., Rabinowitz, J. D. (2006). Conservation of the metabolomic response to starvation across two divergent microbesProc. Natl. Acad. Sci. USA, 103: 19302-19307.  

31. Munger, J., Bajad, S. U., Coller, H. A., Shenk, T., Rabinowitz, J. D. (2006). Dynamics of the cellular metabolome during human cytomegalovirus infectionPLoS Pathogens, 2: 1165.

30. Hess, D. C., Lu, W., Rabinowitz, J. D., Botstein, D. (2006). Ammonium toxicity and potassium limitation in yeast.  PLos Biology, 4: 2012-2023. 

29. Kimball, E., Rabinowitz, J. D. (2006). Identifying decomposition products in extracts of cellular metabolitesAnal. Biochem., 358: 273-80.   

28. Yuan, J., Fowler, W. U., Kimball, E., Lu, W., Rabinowitz, J. D. (2006). Kinetic flux profiling of nitrogen assimilation in Escherichia coliNat. Chem. Biol., 2: 529-530.

27. Bajad, S. U., Lu, W., Kimball, E. H., Yuan, J., Peterson, C., Rabinowitz, J. D. (2006). Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography – tandem mass spectrometryJ. Chrom. A., 1125: 76-88.

26. Rabinowitz, J. D., Lloyd, P. M., Munzar, P., Myers, D. J., Cross, S., Damani, R., Quintana, R., Spyker, D. A., Soni, P., Cassella, J. V. (2006). Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation. J. Pharm. Sci., 95: 2438-2451.

25. Lu, W., Kimball, E., Rabinowitz, J. D. (2006). A high-performance liquid chromatography-tandem mass spectrometry method for quantitation of nitrogen-containing intracellular metabolitesJ. Am. Soc. Mass Spectr., 17: 37-50.

24. Rabinowitz, J. D., Wensley, M., Lloyd, P., Myers, D., Shen, W., Lu, A., Hodges, C., Hale, R., Mufson, D., Zaffaroni, A. (2004). Fast onset medications through thermally generated aerosolsJ. Pharmacol. Exp. Ther., 309: 769-775.

23. Turner-Cobb J. M., Koopman, C., Rabinowitz, J. D., Terr, A. I., Sephton, S. E., Spiegel, D. (2004). The interaction of social network size and stressful life events predict delayed-type hypersensitivity among women with metastatic breast cancerInt. J. Psychophysiol., 54: 241-249.

22. Hall, F. C., Rabinowitz, J. D., Busch, R., Visconti, K. C., Belmares, M., Patil, N. S., Cope, A. P., Patel, S., McConnell, H. M., Mellins, E. D., Sonderstrup, G. (2002). Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexesEur. J. Immunol., 32: 662-670.

21. Patil, N. S., Pashine, A., Belmares, M. P., Liu, W., Kaneshiro, B., Rabinowitz, J., McConnell, H., Mellins, E. D. (2001). Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles. J. Immunol., 167: 7157-7168.

20. Belmares, M. P., Rabinowitz, J. D., Lui, W., Mellins, E. D., McConnell, H. M. (2000). pH stability of HLA-DR4 complexes with antigenic peptidesBiochemistry, 39: 14558-14566.

19. Kasson, P. M., Rabinowitz, J. D., Schmitt, L., Davis, M. M., McConnell, H. M. (2000). Kinetics of peptide binding to the class II MHC protein I-Ek. Biochemistry, 39: 1048-1058.

18. Rabinowitz, J. D., Vrljic, M., Kasson, P. M., Liang, M. N., Busch, R., Boniface, J. J., Davis, M. M., McConnell, H. M. (1998). Formation of a highly peptide-receptive state of class II MHCImmunity, 9: 699-709.

17. Boniface, J. J., Rabinowitz, J. D., Wulfing, C., Hampl, J., Reich, Z., Altman, J. D., Kantor, R. M., Beeson, C., McConnell, H. M., Davis, M. M. (1998). Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligandsImmunity, 9: 459-466.

16. Lee, C., Liang, M. N., Tate, K. M., Rabinowitz, J. D., Beeson, C., Jones, P. P., McConnell, H. M. (1998). Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleftJ. Exp. Med., 187: 1505-1516.

15. Rabinowitz, J. D., Vacchino, J. F., Beeson, C., McConnell, H. M. (1998). Potentiometric measurement of intracellular redox activity. J. Am. Chem. Soc., 120: 2464-2473.

14. Petros, W. P., Rabinowitz, J., Gibbs, J. P., Hall, I. H., Stuart, A. R., Peters, W. P. (1998).Effect of plasma TNF-α on filgrastim-stimulated hematopoiesis in mice and humans.   Pharmacotherapy, 18: 816-823.

13. Rabinowitz, J. D., Liang, M. N., Tate K., Lee C., Beeson C., McConnell H. M. (1997). Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex. Proc. Natl. Acad. Sci. USA, 94: 8702-8707.

12. Rabinowitz, J. D., Rigler P., Carswell-Crumpton, C., Beeson, C., McConnell, H. M. (1997). Screening for novel drug effects with a microphysiometer: a potent effect of clofilium unrelated to potassium channel blockadeLife Sci., 61: PL87-PL94.

11. Elkordy, M., Crump, M., Vredenburgh, J. J., Petros, W. P., Hussein, A., Rubin, P., Ross, M., Gilbert, C., Modlin, C., Meisenberg, B., Coniglio, D., Rabinowitz, J., Laughlin, M., Kurtzberg, J., Peters, W. P. (1997). A phase I trial of recombinant human interleukin-1 beta (OCT-43) following high-dose chemotherapy and autologous bone marrow transplantationBone Marrow Transpl., 19: 315-322.

10. Petros, W. P., Rabinowitz, J., Stuart, A., Peters W. P. (1997). Clinical pharmacology of filgrastim following high-dose chemotherapy and autologous bone marrow transplantationClin. Cancer Res., 3: 705-711.

9. Wulfing, C., Rabinowitz, J. D., Beeson C., Sjaastad M. D., McConnell H. M., Davis M. M. (1997). Kinetics and extent of T cell activation as measured with the calcium signalJ. Exp. Med., 185: 1815-1825.

8. Rabinowitz, J. D., Beeson, C., Wulfing C., Tate K., Allen P. M., Davis M. M., McConnell, H. M. (1996). Altered T cell receptor ligands trigger a subset of early T cell signalsImmunity, 5: 125-135.

7. Rabinowitz, J. D., Beeson C., Lyons D. S., Davis M. M., McConnell, H. M. (1996). Kinetic discrimination in T-cell activationProc. Natl. Acad. Sci. USA, 93: 1401-1405.

6. Beeson, C., Rabinowitz, J., Tate, K., Gutgemann, I., Chien, Y. H., Jones, P. P., Davis, M. M., McConnell, H. M. (1996). Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interfaceJ. Exp. Med., 184: 777-782.

5. Petros, W. P., Rosner, G. L., Rabinowitz, J., Gilbert, C. J., Coniglio, D., Vredenburgh J. J., Ross, M., Peters, W. P. (1996). The pharmacologic effects of recombinant, human colony-stimulating factors and their modulation by theophyllinePharmacotherapy, 16: 742-748.

4. Petros W. P., Rabinowitz, J., Stuart A. R., Gupton C., Alderman, E. M., Peters, W. P. (1994). Elevated endogenous serum macrophage colony-stimulating factor in the early stage of fungemia following bone marrow transplantationExp. Hematol., 22: 582-586.

3. Rabinowitz, J., Petros, W. P., Peters, W. P. (1994). Cytokine kinetics: Clinical pharmacology studies complementing recombinant growth factor trialsCancer Bulletin, 46: 40-47.

2. Rabinowitz, J., Petros, W. P., Stuart, A. R., Peters, W. P. (1993). Characterization of endogenous cytokine concentrations after high-dose chemotherapy with autologous bone marrow supportBlood, 81: 2452-2459.

1. Petros W. P., Rabinowitz, J., Stuart, A. R., Gilbert, C. J., Kanakura, Y., Griffin, J. D., Peters, W. P. (1992). Disposition of recombinant human granulocyte-macrophage colony-stimulating factor in patients receiving high-dose chemotherapy and autologous bone marrow support. Blood, 80: 1135-1140.