SprE levels are growth phase regulated in a sigma(S)-dependent manner at the level of translation

Author
Publication Year
2000

Type

Journal Article
Abstract

SprE regulates sigma(S) levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is sigma(S) dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and sigma(S) function within a regulatory feedback loop.

Journal
J Bacteriol
Volume
182
Issue
14
Pages
4117-20
Date Published
07/2000
ISSN Number
0021-9193
Alternate Journal
J Bacteriol
PMID
10869095