Research Projects

  • Postdoctoral research in The Hong Kong Polytechnic University, HK, China, Aug. 2014 - present,
    Project: A Unified Machine Learning Framework for Classifier Design with Applications to Cancer Diagnosis.
    1. Develop biologically-interpretable approaches for protein subcellular localization prediction.
    2. Detect protein complexes in protein-protein interaction datasets.
    3. Integrate sequence-based and network-based approaches into interactomes to unravel the mechanisms of biological systems.

  • Exchange program in The Johns Hopkins School of Medicine, MD, USA and CBIL lab of Virginia Tech, VA, USA , Spring 2013 - Summer 2013,
    Project: Clinical Proteomic Tumor Analysis Consortium (CPTAC).
      1. Construct customized sample-specific protein sequence databases.
      2. Research on proteogenomic integration using customized protein sequence databases derived from TCGA genomic data.
      3. Apply protein subcellular localization prediction methods in ovarian cancer sample post-translational modification (PTM) study.

    • Doctoral research in The Hong Kong Polytechnic University, HK, China, Aug. 2010 - present,
      Project: Fusion of Functional Site Detection and Kernel Discriminant Analysis for Biological Sequence Classification.
        1. Research on biological feature extraction and dimension-reduction approaches.
        2. Discover Gene-Ontology based semantic similarity and hierarchical-structure information and apply them into protein subcellular localization prediction.
        3. Improve multi-label classifiers to adapt to our multi-location protein subcellular localization problems.

      • Doctoral research in The Hong Kong Polytechnic University, HK, China, Aug. 2010 - present,
        Project: Discriminative Models for Biological Sequence Labeling and Segmentation.
          1. Predict protein subcellular localization.
          2. Extract Gene Ontology information and its application in sequence analysis and function prediction.
          3. Design classifiers for computational biology.
            • Undergraduate research in Wuhan University, China, Jan. 2010 – Jun. 2010,
              Project: Design and Simulation of Variable-Rate CDMA-based MAC Protocol.
              1. Research on communication of underwater acoustic sensor networks.
              2. Design protocols for low-noise variable-rate underwater communication.
              • Undergraduate research in Wuhan University, China, Mar. 2009 – Jan. 2010,
                Project: Continuous Data Flow Transmission within Speech Signals.
              1. Develop digital watermarking technology for hidden communication.
              2. Research on speech signal processing for lossless information transmission.