Graded bidirectional synaptic plasticity is composed of switch-like unitary events

Citation:

O'Connor, Daniel H, Gayle M Wittenberg, and Samuel S-H Wang. “Graded bidirectional synaptic plasticity is composed of switch-like unitary events”. Proc Natl Acad Sci U S A 102.27 (2005): , 102, 27, 9679-84. Web.

Date Published:

2005 Jul 05

ISSN:

0027-8424

Abstract:

Biological information storage events are often rapid transitions between discrete states. In neural systems, the initiation of bidirectional plasticity by all-or-none events may help confer robustness on memory storage. Here, we report that at CA3-CA1 hippocampal synapses, individual potentiation and depression plasticity events are discrete and heterogeneous in nature. Individual synapses began from extreme high and low strength states. Unitary plasticity events were all-or-none and drove synaptic strength between extremes in <1 min. Under naïve conditions, approximately three-fourths of synapses began in a low-strength state. The timing of these unitary events can account for the time course of macroscopic synaptic plasticity.

DOI:

10.1073/pnas.0502332102

Alternate Journal:

Proc. Natl. Acad. Sci. U.S.A.