Coordinating Cell Cycle Remodeling with Transcriptional Activation at the Drosophila MBT.

Citation:

Blythe, Shelby A, and Eric F Wieschaus. “Coordinating Cell Cycle Remodeling with Transcriptional Activation at the Drosophila MBT.”. Curr Top Dev Biol 113 (2015): , 113, 113-48. Web.

Date Published:

2015

ISSN:

1557-8933

Abstract:

During the maternal-to-zygotic transition (MZT), major changes in cell cycle regulation coincide with large-scale zygotic genome activation. In this chapter, we discuss the current understanding of how the cell cycle is remodeled over the course of the Drosophila MZT, and how the temporal precision of this event is linked to contemporaneous alterations in genome-wide chromatin structure and transcriptional activity. The cell cycle is initially lengthened during the MZT by activation of the DNA replication checkpoint but, subsequently, zygotically supplied factors are essential for establishing lasting modifications to the cell cycle.

DOI:

10.1016/bs.ctdb.2015.06.002

Alternate Journal:

Curr. Top. Dev. Biol.
Last updated on 01/17/2020