Junctions as organizing centers in epithelial cells? A fly perspective.


Lecuit, Thomas, and Eric Wieschaus. “Junctions as organizing centers in epithelial cells? A fly perspective.”. Traffic 32 (2002): , 3, 2, 92-7. Print.

Date Published:

2002 Feb




Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such as the orientation of the division apparatus.

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Last updated on 01/17/2020